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Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis
INTRODUCTION: Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the evidence remains inconclusive. This meta-analysis...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666188/ https://www.ncbi.nlm.nih.gov/pubmed/38025481 http://dx.doi.org/10.3389/fpsyt.2023.1264998 |
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author | Pacho, Malein Aymerich, Claudia Pedruzo, Borja Salazar de Pablo, Gonzalo Sesma, Eva Bordenave, Marta Dieguez, Rodrigo Lopez-Zorroza, Itziar Herrero, Jon Laborda, Maria Fernandez-Rivas, Aranzazu Garcia-Rizo, Clemente Gonzalez-Torres, Miguel Angel Catalan, Ana |
author_facet | Pacho, Malein Aymerich, Claudia Pedruzo, Borja Salazar de Pablo, Gonzalo Sesma, Eva Bordenave, Marta Dieguez, Rodrigo Lopez-Zorroza, Itziar Herrero, Jon Laborda, Maria Fernandez-Rivas, Aranzazu Garcia-Rizo, Clemente Gonzalez-Torres, Miguel Angel Catalan, Ana |
author_sort | Pacho, Malein |
collection | PubMed |
description | INTRODUCTION: Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the evidence remains inconclusive. This meta-analysis aims to comprehensively assess the effects of different substances on PPD risk, exploring potential modifiers and confounding factors. OBJECTIVES: To examine the proportion of PPD among substance users during pregnancy, compared to non-users, and investigate the specific risk associated with different substances (tobacco, alcohol, and non-specified substance use/multiple substance use). METHODS: A systematic literature search was conducted from inception to November 2022 using the Web of Science database (Clarivate Analytics), incorporating Web of Science Core Collection, the BIOSIS Citation Index, the KCI-Korean Journal Database, MEDLINE(®), the Russian Science Citation Index, the SciELO Citation Index, and the Cochrane Central Register of Reviews, and Ovid/PsycINFO databases. Inclusion criteria comprised original studies with pregnant women, using validated depression scales and substance use reporting. RESULTS: Among the 26 included studies, encompassing 514,441 women, the pooled prevalence of PPD among substance users during pregnancy was 29% (95% CI 25–33). Meta-analyzes revealed an overall odds ratio (OR) of 3.67 (95% CI 2.31–5.85, p < 0.01) indicating a significantly higher risk of PPD among substance users compared to non-users. Subgroup analyzes demonstrated a higher risk for women with non-specified or multiple substance use (OR 4.67, 95% CI 2.59–8.41; p < 0.01) and tobacco use (OR 4.01, 95% CI 2.23–7.20; p < 0.01). Alcohol use showed a trend toward higher risk that did not reach statistical significance (OR 1.88, 95% CI 1.00–3.55; p = 0.051). CONCLUSION: This meta-analysis provides evidence of an increased risk of PPD among pregnant substance users, particularly those using multiple substances or tobacco. However, caution is needed in interpreting the association with alcohol use due to its non-significant result. SYSTEMATIC REVIEW REGISTRATION: This study protocol was registered at PROSPERO (registration number: CCRD42022375500). |
format | Online Article Text |
id | pubmed-10666188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106661882023-11-09 Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis Pacho, Malein Aymerich, Claudia Pedruzo, Borja Salazar de Pablo, Gonzalo Sesma, Eva Bordenave, Marta Dieguez, Rodrigo Lopez-Zorroza, Itziar Herrero, Jon Laborda, Maria Fernandez-Rivas, Aranzazu Garcia-Rizo, Clemente Gonzalez-Torres, Miguel Angel Catalan, Ana Front Psychiatry Psychiatry INTRODUCTION: Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the evidence remains inconclusive. This meta-analysis aims to comprehensively assess the effects of different substances on PPD risk, exploring potential modifiers and confounding factors. OBJECTIVES: To examine the proportion of PPD among substance users during pregnancy, compared to non-users, and investigate the specific risk associated with different substances (tobacco, alcohol, and non-specified substance use/multiple substance use). METHODS: A systematic literature search was conducted from inception to November 2022 using the Web of Science database (Clarivate Analytics), incorporating Web of Science Core Collection, the BIOSIS Citation Index, the KCI-Korean Journal Database, MEDLINE(®), the Russian Science Citation Index, the SciELO Citation Index, and the Cochrane Central Register of Reviews, and Ovid/PsycINFO databases. Inclusion criteria comprised original studies with pregnant women, using validated depression scales and substance use reporting. RESULTS: Among the 26 included studies, encompassing 514,441 women, the pooled prevalence of PPD among substance users during pregnancy was 29% (95% CI 25–33). Meta-analyzes revealed an overall odds ratio (OR) of 3.67 (95% CI 2.31–5.85, p < 0.01) indicating a significantly higher risk of PPD among substance users compared to non-users. Subgroup analyzes demonstrated a higher risk for women with non-specified or multiple substance use (OR 4.67, 95% CI 2.59–8.41; p < 0.01) and tobacco use (OR 4.01, 95% CI 2.23–7.20; p < 0.01). Alcohol use showed a trend toward higher risk that did not reach statistical significance (OR 1.88, 95% CI 1.00–3.55; p = 0.051). CONCLUSION: This meta-analysis provides evidence of an increased risk of PPD among pregnant substance users, particularly those using multiple substances or tobacco. However, caution is needed in interpreting the association with alcohol use due to its non-significant result. SYSTEMATIC REVIEW REGISTRATION: This study protocol was registered at PROSPERO (registration number: CCRD42022375500). Frontiers Media S.A. 2023-11-09 /pmc/articles/PMC10666188/ /pubmed/38025481 http://dx.doi.org/10.3389/fpsyt.2023.1264998 Text en Copyright © 2023 Pacho, Aymerich, Pedruzo, Salazar de Pablo, Sesma, Bordenave, Dieguez, Lopez-Zorroza, Herrero, Laborda, Fernandez-Rivas, Garcia-Rizo, Gonzalez-Torres and Catalan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Pacho, Malein Aymerich, Claudia Pedruzo, Borja Salazar de Pablo, Gonzalo Sesma, Eva Bordenave, Marta Dieguez, Rodrigo Lopez-Zorroza, Itziar Herrero, Jon Laborda, Maria Fernandez-Rivas, Aranzazu Garcia-Rizo, Clemente Gonzalez-Torres, Miguel Angel Catalan, Ana Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis |
title | Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis |
title_full | Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis |
title_fullStr | Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis |
title_full_unstemmed | Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis |
title_short | Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis |
title_sort | substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666188/ https://www.ncbi.nlm.nih.gov/pubmed/38025481 http://dx.doi.org/10.3389/fpsyt.2023.1264998 |
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