Cargando…

In Silico and In Vitro Analyses to Repurpose Quercetin as a Human Pancreatic α-Amylase Inhibitor

[Image: see text] Human pancreatic α-amylase (HPA), situated at the apex of the starch digestion hierarchy, is an attractive therapeutic approach to precisely regulate blood glucose levels, thereby efficiently managing diabetes. Polyphenols offer a natural and multifaceted approach to moderate postp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raut, Bimal K., Upadhyaya, Siddha Raj, Bashyal, Jyoti, Parajuli, Niranjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666247/ https://www.ncbi.nlm.nih.gov/pubmed/38027372 http://dx.doi.org/10.1021/acsomega.3c05082

Ejemplares similares

West Mexico Berries Modulate α-Amylase, α-Glucosidase and Pancreatic Lipase Using In Vitro and In Silico Approaches
por: Virgen-Carrillo, Carmen Alejandrina, et al.
Publicado: (2022)

α-Amylase Inhibitory Activity of Catunaregam spinosa (Thunb.) Tirveng.: In Vitro and In Silico Studies
por: Timalsina, Deepak, et al.
Publicado: (2021)

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes
por: Riyaphan, Jirawat, et al.
Publicado: (2021)

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors
por: Zheng, Peng-Fei, et al.
Publicado: (2021)

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase
por: Khan, Shoaib, et al.
Publicado: (2022)

Antidiabetic Activity of Ruellia tuberosa L., Role of α-Amylase Inhibitor: In Silico, In Vitro, and In Vivo Approaches
por: Ratna Wulan, Dyah, et al.
Publicado: (2015)

Inhibition of Sunn Pest, Eurygaster integriceps, α-Amylases by α-Amylase Inhibitors (T-αAI) from Triticale
por: Mehrabadi, Mohammad, et al.
Publicado: (2010)

Reflection on design and testing of pancreatic alpha-amylase inhibitors: an in silico comparison between rat and rabbit enzyme models
por: Khalil-Moghaddam, Shiva, et al.
Publicado: (2012)

Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors
por: Quan, Nguyen Van, et al.
Publicado: (2019)

Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase
por: Ćorković, Ina, et al.
Publicado: (2022)

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase
por: Tysoe, Christina R., et al.
Publicado: (2019)

Design and evaluation of chalconeimine derivatives as α-amylase inhibitors
por: Balu, Prithivirajan, et al.
Publicado: (2019)

Mangosteen Metabolites as Promising Alpha-Amylase Inhibitor Candidates: In Silico and In Vitro Evaluations
por: Omar, Abdelsattar M., et al.
Publicado: (2022)

Chemical Group Profiling, In Vitro and In Silico Evaluation of Aristolochia ringens on α-Amylase and α-Glucosidase Activity
por: Ahmad, J. B., et al.
Publicado: (2021)

In Vitro and In Silico Evaluation for the Inhibitory Action of O. basilicum Methanol Extract on α-Glucosidase and α-Amylase
por: Shanak, Siba, et al.
Publicado: (2021)

Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-α-Amylase, and Anti-α-Glucosidase: In Vitro and In Silico Approaches
por: Alshehri, Osama M., et al.
Publicado: (2022)

Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase
por: Goldbach, Leander, et al.
Publicado: (2019)

Inhibitory effect of a weight-loss Chinese herbal formula RCM-107 on pancreatic α-amylase activity: Enzymatic and in silico approaches
por: Luo, Shiqi, et al.
Publicado: (2020)

Drug screening of α‐amylase inhibitors as candidates for treating diabetes
por: Alp, Meryem, et al.
Publicado: (2023)

In silico analysis of the α-amylase family GH57: eventual subfamilies reflecting enzyme specificities
por: Martinovičová, Mária, et al.
Publicado: (2018)

Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis
por: Marahatha, Rishab, et al.
Publicado: (2021)

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies
por: Khan, Yousaf, et al.
Publicado: (2022)

The Regulation of Hypoxia Inducible Factor (HIF)1α Expression by Quercetin: an In Silico Study
por: Wahyuningsih, Sri Puji Astuti, et al.
Publicado: (2022)

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors
por: Ke, Jun-Jie, et al.
Publicado: (2022)

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β
por: Kaushal, Jyoti B., et al.
Publicado: (2021)

Cloning, expression, and characterization of a porcine pancreatic α-amylase in Pichia pastoris
por: Sun, Lv-hui, et al.
Publicado: (2018)

Genetically modified α-amylase inhibitor peas are not specifically allergenic in mice
por: Reiner, D, et al.
Publicado: (2013)

Genetically Modified α-Amylase Inhibitor Peas Are Not Specifically Allergenic in Mice
por: Lee, Rui-Yun, et al.
Publicado: (2013)

Genetic architecture underlying the expression of eight α-amylase trypsin inhibitors
por: EL Hassouni , Khaoula, et al.
Publicado: (2021)

Substituted Benzimidazole Analogues as Potential α-Amylase Inhibitors and Radical Scavengers
por: Akande, Akinsola Adegboye, et al.
Publicado: (2021)

Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies
por: Nguyen, Tan Khanh, et al.
Publicado: (2023)

Phytochemical Analysis and Antioxidant and Antidiabetic Activities of Extracts from Bergenia ciliata, Mimosa pudica, and Phyllanthus emblica
por: Sapkota, Basanta Kumar, et al.
Publicado: (2022)

In vitro inhibitory effects of plant-based foods and their combinations on intestinal α-glucosidase and pancreatic α-amylase
por: Adisakwattana, Sirichai, et al.
Publicado: (2012)

Multitarget Action of Xanthones from Garcinia mangostana against α-Amylase, α-Glucosidase and Pancreatic Lipase
por: Cardozo-Muñoz, Juan, et al.
Publicado: (2022)

Inhibitors of α‐amylase and α‐glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia
por: Gong, Lingxiao, et al.
Publicado: (2020)

Phytochemical Profiling in Conjunction with In Vitro and In Silico Studies to Identify Human α-Amylase Inhibitors in Leucaena leucocephala (Lam.) De Wit for the Treatment of Diabetes Mellitus
por: Renganathan, Senthil, et al.
Publicado: (2021)

α-Amylase inhibitor-1 gene from Phaseolus vulgaris expressed in Coffea arabica plants inhibits α-amylases from the coffee berry borer pest
por: Barbosa, Aulus EAD, et al.
Publicado: (2010)

Molecular Engineering of the Geobacillus stearothermophilus α-Amylase and Cel5E from Chlostridium thermocellim; In Silico Approach
por: Torktaz, Ibrahim, et al.
Publicado: (2018)

In silico and in vitro screening of licensed antimalarial drugs for repurposing as inhibitors of hepatitis E virus
por: Tietcheu Galani, Borris Rosnay, et al.
Publicado: (2021)

Unlocking potential inhibitors for Bruton's tyrosine kinase through in-silico drug repurposing strategies
por: Alrouji, Mohammed, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dc7elvuh0311aa0k81fjbi3jv7