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Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression

Melanoma presents increasing prevalence and poor outcomes. Progression to aggressive stages is characterized by overexpression of the transcription factor E2F1 and activation of downstream prometastatic gene regulatory networks (GRNs). Appropriate therapeutic manipulation of the E2F1-governed GRNs h...

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Detalles Bibliográficos
Autores principales:	Singh, Nivedita, Khan, Faiz M, Bala, Lakshmi, Vera, Julio, Wolkenhauer, Olaf, Pützer, Brigitte, Logotheti, Stella, Gupta, Shailendra K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666365/ https://www.ncbi.nlm.nih.gov/pubmed/37993971 http://dx.doi.org/10.1186/s13065-023-01082-2

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