Targeting oncogenic TERT promoter variants by allele-specific epigenome editing

BACKGROUND: Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. Silencing of such dominantly activated oncogenic alleles, thus, is a promising strategy to treat cancer. Recently, allele-specific epigenome editing (ASEE) has been d...

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Detalles Bibliográficos
Autores principales: Kouroukli, Alexandra G., Rajaram, Nivethika, Bashtrykov, Pavel, Kretzmer, Helene, Siebert, Reiner, Jeltsch, Albert, Bens, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666398/
https://www.ncbi.nlm.nih.gov/pubmed/37993930
http://dx.doi.org/10.1186/s13148-023-01599-2

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