Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

BACKGROUND: The lactate receptor GPR81 contributes to cancer development through unclear mechanisms. Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo growth of breast cancer cells and study the molecular mechanisms involved. METHODS: GPR81 was stably knocked down (KD) in...

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Detalles Bibliográficos
Autores principales: Lundø, Kathrine, Dmytriyeva, Oksana, Spøhr, Louise, Goncalves-Alves, Eliana, Yao, Jiayi, Blasco, Laia P., Trauelsen, Mette, Ponniah, Muthulakshmi, Severin, Marc, Sandelin, Albin, Kveiborg, Marie, Schwartz, Thue W., Pedersen, Stine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666402/
https://www.ncbi.nlm.nih.gov/pubmed/37993804
http://dx.doi.org/10.1186/s12885-023-11631-6

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