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P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages

BACKGROUND: The purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 receptor stimulation triggers processing and release of the pro-inflammatory cytokine interleukin (IL)-1β by activation of the NLRP3 inflammasome; however, the underlying...

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Detalles Bibliográficos
Autores principales:	Bockstiegel, Judith, Engelhardt, Jonas, Weindl, Günther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666422/ https://www.ncbi.nlm.nih.gov/pubmed/37996864 http://dx.doi.org/10.1186/s12964-023-01356-1

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