Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes

A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin...

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Autores principales: Hebebrand, Johannes, Antel, Jochen, von Piechowski, Linda, Kiewert, Cordula, Stüve, Burkhard, Gradl-Dietsch, Gertraud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666640/
https://www.ncbi.nlm.nih.gov/pubmed/38025476
http://dx.doi.org/10.3389/fpsyt.2023.1267495
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author Hebebrand, Johannes
Antel, Jochen
von Piechowski, Linda
Kiewert, Cordula
Stüve, Burkhard
Gradl-Dietsch, Gertraud
author_facet Hebebrand, Johannes
Antel, Jochen
von Piechowski, Linda
Kiewert, Cordula
Stüve, Burkhard
Gradl-Dietsch, Gertraud
author_sort Hebebrand, Johannes
collection PubMed
description A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11 days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME/CSF associated with substantial weight loss.
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spelling pubmed-106666402023-11-09 Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes Hebebrand, Johannes Antel, Jochen von Piechowski, Linda Kiewert, Cordula Stüve, Burkhard Gradl-Dietsch, Gertraud Front Psychiatry Psychiatry A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11 days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME/CSF associated with substantial weight loss. Frontiers Media S.A. 2023-11-09 /pmc/articles/PMC10666640/ /pubmed/38025476 http://dx.doi.org/10.3389/fpsyt.2023.1267495 Text en Copyright © 2023 Hebebrand, Antel, von Piechowski, Kiewert, Stüve and Gradl-Dietsch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Hebebrand, Johannes
Antel, Jochen
von Piechowski, Linda
Kiewert, Cordula
Stüve, Burkhard
Gradl-Dietsch, Gertraud
Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
title Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
title_full Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
title_fullStr Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
title_full_unstemmed Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
title_short Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
title_sort case report: rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666640/
https://www.ncbi.nlm.nih.gov/pubmed/38025476
http://dx.doi.org/10.3389/fpsyt.2023.1267495
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