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Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone
BACKGROUND: Teriparatide (TPTD) should be followed by an antiresorptive to maximize bone mineral density gain and anti-fracture protection. Infrequent zoledronic acid (ZOL) administration has demonstrated effectiveness. The duration of ZOL effect following TPTD is unknown. OBJECTIVE: To evaluate the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666713/ https://www.ncbi.nlm.nih.gov/pubmed/38028331 http://dx.doi.org/10.1177/20420188231213639 |
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author | Giveon, Sharon Zacay, Galia Vered, Iris Foldes, A. Joseph Tripto-Shkolnik, Liana |
author_facet | Giveon, Sharon Zacay, Galia Vered, Iris Foldes, A. Joseph Tripto-Shkolnik, Liana |
author_sort | Giveon, Sharon |
collection | PubMed |
description | BACKGROUND: Teriparatide (TPTD) should be followed by an antiresorptive to maximize bone mineral density gain and anti-fracture protection. Infrequent zoledronic acid (ZOL) administration has demonstrated effectiveness. The duration of ZOL effect following TPTD is unknown. OBJECTIVE: To evaluate the effect of ZOL on bone resorption marker in a post-TPTD versus ZOL-alone scenario in osteoporotic patients. DESIGN: Retrospective cohort study. METHODS: Patients treated with TPTD followed by ZOL (TPTD–ZOL) or with a single ZOL infusion were identified in the database of a tertiary referral center. Clinical and laboratory data, including C-terminal telopeptide of type I collagen (CTX) following ZOL treatment, were compared. RESULTS: Twenty-six patients (93% women) treated with TPTD–ZOL and 41 with ZOL were comparable in age (median 70.1 versus 69.6 years, p = 0.6) and sex. Timing of CTX measurement post-ZOL was the same, median 1.0 year. CTX was lower following TPTD–ZOL (median 142.1 versus 184.2 pg/mL, p = 0.005). In a multivariable regression model (controlled for baseline characteristics), pretreatment with TPTD strongly predicted CTX <150 pg/mL, 1 year following ZOL (odds ratio = 7.5, 95% CI 1.3–58.1, p = 0.03). In a subgroup with sequential CTX measurements following one ZOL, significantly lower levels persisted in the TPTD–ZOL group for a median of 4.4 years follow-up. CONCLUSION: ZOL-administered sequential to TPTD yielded deeper and more prolonged bone resorption suppression than ZOL alone. Prospective data are needed to confirm whether in a sequential treatment scenario, subsequent ZOL dosing interval should be less frequent. |
format | Online Article Text |
id | pubmed-10666713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-106667132023-11-22 Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone Giveon, Sharon Zacay, Galia Vered, Iris Foldes, A. Joseph Tripto-Shkolnik, Liana Ther Adv Endocrinol Metab Original Research BACKGROUND: Teriparatide (TPTD) should be followed by an antiresorptive to maximize bone mineral density gain and anti-fracture protection. Infrequent zoledronic acid (ZOL) administration has demonstrated effectiveness. The duration of ZOL effect following TPTD is unknown. OBJECTIVE: To evaluate the effect of ZOL on bone resorption marker in a post-TPTD versus ZOL-alone scenario in osteoporotic patients. DESIGN: Retrospective cohort study. METHODS: Patients treated with TPTD followed by ZOL (TPTD–ZOL) or with a single ZOL infusion were identified in the database of a tertiary referral center. Clinical and laboratory data, including C-terminal telopeptide of type I collagen (CTX) following ZOL treatment, were compared. RESULTS: Twenty-six patients (93% women) treated with TPTD–ZOL and 41 with ZOL were comparable in age (median 70.1 versus 69.6 years, p = 0.6) and sex. Timing of CTX measurement post-ZOL was the same, median 1.0 year. CTX was lower following TPTD–ZOL (median 142.1 versus 184.2 pg/mL, p = 0.005). In a multivariable regression model (controlled for baseline characteristics), pretreatment with TPTD strongly predicted CTX <150 pg/mL, 1 year following ZOL (odds ratio = 7.5, 95% CI 1.3–58.1, p = 0.03). In a subgroup with sequential CTX measurements following one ZOL, significantly lower levels persisted in the TPTD–ZOL group for a median of 4.4 years follow-up. CONCLUSION: ZOL-administered sequential to TPTD yielded deeper and more prolonged bone resorption suppression than ZOL alone. Prospective data are needed to confirm whether in a sequential treatment scenario, subsequent ZOL dosing interval should be less frequent. SAGE Publications 2023-11-22 /pmc/articles/PMC10666713/ /pubmed/38028331 http://dx.doi.org/10.1177/20420188231213639 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Giveon, Sharon Zacay, Galia Vered, Iris Foldes, A. Joseph Tripto-Shkolnik, Liana Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone |
title | Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone |
title_full | Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone |
title_fullStr | Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone |
title_full_unstemmed | Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone |
title_short | Zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone |
title_sort | zoledronic acid sequential to teriparatide may promote greater inhibition of bone resorption than zoledronic acid alone |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666713/ https://www.ncbi.nlm.nih.gov/pubmed/38028331 http://dx.doi.org/10.1177/20420188231213639 |
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