Targeted depletion of TRBV9(+) T cells as immunotherapy in a patient with ankylosing spondylitis

Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune therapy, but disease-associated T cell receptors (TCRs) and cognate antigenic epitopes remained...

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Detalles Bibliográficos
Autores principales: Britanova, Olga V., Lupyr, Kseniia R., Staroverov, Dmitry B., Shagina, Irina A., Aleksandrov, Alexey A., Ustyugov, Yakov Y., Somov, Dmitry V., Klimenko, Alesia, Shostak, Nadejda A., Zvyagin, Ivan V., Stepanov, Alexey V., Merzlyak, Ekaterina M., Davydov, Alexey N., Izraelson, Mark, Egorov, Evgeniy S., Bogdanova, Ekaterina A., Vladimirova, Anna K., Iakovlev, Pavel A., Fedorenko, Denis A., Ivanov, Roman A., Skvortsova, Veronika I., Lukyanov, Sergey, Chudakov, Dmitry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667094/
https://www.ncbi.nlm.nih.gov/pubmed/37872223
http://dx.doi.org/10.1038/s41591-023-02613-z

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