Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast

Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with marketed pharmaceutical activities against a wide range of indications, including cancer, malaria and hypertension. Halogenated MIAs have shown improved pharmaceutical properties; however, synthesis of new-t...

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Detalles Bibliográficos
Autores principales: Bradley, Samuel A., Lehka, Beata J., Hansson, Frederik G., Adhikari, Khem B., Rago, Daniela, Rubaszka, Paulina, Haidar, Ahmad K., Chen, Ling, Hansen, Lea G., Gudich, Olga, Giannakou, Konstantina, Lengger, Bettina, Gill, Ryan T., Nakamura, Yoko, de Bernonville, Thomas Dugé, Koudounas, Konstantinos, Romero-Suarez, David, Ding, Ling, Qiao, Yijun, Frimurer, Thomas M., Petersen, Anja A., Besseau, Sébastien, Kumar, Sandeep, Gautron, Nicolas, Melin, Celine, Marc, Jillian, Jeanneau, Remi, O’Connor, Sarah E., Courdavault, Vincent, Keasling, Jay D., Zhang, Jie, Jensen, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667104/
https://www.ncbi.nlm.nih.gov/pubmed/37932529
http://dx.doi.org/10.1038/s41589-023-01430-2

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