Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in the basal ganglia despite the ubiquitous expression of mutant huntingtin. The molecular mechanisms underlying this region-specific neuronal degeneration and how these relate...

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Detalles Bibliográficos
Autores principales: Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667107/
https://www.ncbi.nlm.nih.gov/pubmed/37814059
http://dx.doi.org/10.1038/s41591-023-02566-3

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