Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains

We describe the complete synthesis, assembly, debugging, and characterization of a synthetic 404,963 bp chromosome, synIX (synthetic chromosome IX). Combined chromosome construction methods were used to synthesize and integrate its left arm (synIXL) into a strain containing previously described synI...

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Detalles Bibliográficos
Autores principales: McCulloch, Laura H., Sambasivam, Vijayan, Hughes, Amanda L., Annaluru, Narayana, Ramalingam, Sivaprakash, Fanfani, Viola, Lobzaev, Evgenii, Mitchell, Leslie A., Cai, Jitong, Jiang, Hua, LaCava, John, Taylor, Martin S., Bishai, William R., Stracquadanio, Giovanni, Steinmetz, Lars M., Bader, Joel S., Zhang, Weimin, Boeke, Jef D., Chandrasegaran, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667316/
https://www.ncbi.nlm.nih.gov/pubmed/38020974
http://dx.doi.org/10.1016/j.xgen.2023.100419

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