Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects

Synthetic chromosome engineering is a complex process due to the need to identify and repair growth defects and deal with combinatorial gene essentiality when rearranging chromosomes. To alleviate these issues, we have demonstrated novel approaches for repairing and rearranging synthetic Saccharomyc...

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Detalles Bibliográficos
Autores principales: Williams, Thomas C., Kroukamp, Heinrich, Xu, Xin, Wightman, Elizabeth L.I., Llorente, Briardo, Borneman, Anthony R., Carpenter, Alexander C., Van Wyk, Niel, Meier, Felix, Collier, Thomas R.V., Espinosa, Monica I., Daniel, Elizabeth L., Walker, Roy S.K., Cai, Yizhi, Nevalainen, Helena K.M., Curach, Natalie C., Deveson, Ira W., Mercer, Timothy R., Johnson, Daniel L., Mitchell, Leslie A., Bader, Joel S., Stracquadanio, Giovanni, Boeke, Jef D., Goold, Hugh D., Pretorius, Isak S., Paulsen, Ian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667330/
https://www.ncbi.nlm.nih.gov/pubmed/38020977
http://dx.doi.org/10.1016/j.xgen.2023.100379

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