Alternative splicing of its 5′-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

Aberrant skipping of coding exons in CD19 and CD22 compromises the response to immunotherapy in B-cell malignancies. Here, we showed that the MS4A1 gene encoding human CD20 also produces several messenger RNA (mRNA) isoforms with distinct 5′ untranslated regions. Four variants (V1-4) were detected u...

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Detalles Bibliográficos
Autores principales: Ang, Zhiwei, Paruzzo, Luca, Hayer, Katharina E., Schmidt, Carolin, Torres Diz, Manuel, Xu, Feng, Zankharia, Urvi, Zhang, Yunlin, Soldan, Samantha, Zheng, Sisi, Falkenstein, Catherine D., Loftus, Joseph P., Yang, Scarlett Y., Asnani, Mukta, King Sainos, Patricia, Pillai, Vinodh, Chong, Emeline, Li, Marilyn M., Tasian, Sarah K., Barash, Yoseph, Lieberman, Paul M., Ruella, Marco, Schuster, Stephen J., Thomas-Tikhonenko, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667349/
https://www.ncbi.nlm.nih.gov/pubmed/37683180
http://dx.doi.org/10.1182/blood.2023020400

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