SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation

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Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to inflammatory, metabolic, and oxidative stressors. We previously reported that myeloid SIRT1 regulates the inflamed liver’s canonical pyroptosis cell death pathway. However, whether/how hepatocyte SIRT1 is engaged in progr...

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Detalles Bibliográficos
Autores principales: Kadono, Kentaro, Kojima, Hidenobu, Yao, Siyuan, Kageyama, Shoichi, Nakamura, Kojiro, Hirao, Hirofumi, Ito, Takahiro, Dery, Kenneth J., Farmer, Douglas G., Kaldas, Fady M., Li, Xiaoling, Kupiec-Weglinski, Jerzy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667508/
https://www.ncbi.nlm.nih.gov/pubmed/37996424
http://dx.doi.org/10.1038/s41419-023-06221-0

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