Reversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML

The transcription factor MYB plays a pivotal role in haematopoietic homoeostasis and its aberrant expression is involved in the genesis and maintenance of acute myeloid leukaemia (AML). We have previously demonstrated that not all AML subtypes display the same dependency on MYB expression and that s...

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Detalles Bibliográficos
Autores principales: Negri, A., Ward, C., Bucci, A., D’Angelo, G., Cauchy, P., Radesco, A., Ventura, A. B., Walton, D. S., Clarke, M., Mandriani, B., Pappagallo, S. A., Mondelli, P., Liao, K., Gargano, G., Zaccaria, G. M., Viggiano, L., Lasorsa, F. M., Ahmed, A., Di Molfetta, D., Fiermonte, G., Cives, M., Guarini, A., Vegliante, M. C., Ciavarella, S., Frampton, J., Volpe, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667525/
https://www.ncbi.nlm.nih.gov/pubmed/37996430
http://dx.doi.org/10.1038/s41419-023-06276-z

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