Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function

We designed and synthesized synI, which is ∼21.6% shorter than native chrI, the smallest chromosome in Saccharomyces cerevisiae. SynI was designed for attachment to another synthetic chromosome due to concerns surrounding potential instability and karyotype imbalance and is now attached to synIII, y...

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Detalles Bibliográficos
Autores principales: Luo, Jingchuan, Vale-Silva, Luis A., Raghavan, Adhithi R., Mercy, Guillaume, Heldrich, Jonna, Sun, Xiaoji, Li, Mingyu Kenneth, Zhang, Weimin, Agmon, Neta, Yang, Kun, Cai, Jitong, Stracquadanio, Giovanni, Thierry, Agnès, Zhao, Yu, Coelho, Camila, McCulloch, Laura H., Lauer, Stephanie, Kaback, David B., Bader, Joel S., Mitchell, Leslie A., Mozziconacci, Julien, Koszul, Romain, Hochwagen, Andreas, Boeke, Jef D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667551/
https://www.ncbi.nlm.nih.gov/pubmed/38020967
http://dx.doi.org/10.1016/j.xgen.2023.100439

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