Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration

Chromosome-level design-build-test-learn cycles (chrDBTLs) allow systematic combinatorial reconfiguration of chromosomes with ease. Here, we established chrDBTL with a redesigned synthetic Saccharomyces cerevisiae chromosome XV, synXV. We designed and built synXV to harbor strategically inserted fea...

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Detalles Bibliográficos
Autores principales: Foo, Jee Loon, Kitano, Shohei, Susanto, Adelia Vicanatalita, Jin, Zhu, Lin, Yicong, Luo, Zhouqing, Huang, Linsen, Liang, Zhenzhen, Mitchell, Leslie A., Yang, Kun, Wong, Adison, Cai, Yizhi, Cai, Jitong, Stracquadanio, Giovanni, Bader, Joel S., Boeke, Jef D., Dai, Junbiao, Chang, Matthew Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667554/
https://www.ncbi.nlm.nih.gov/pubmed/38020970
http://dx.doi.org/10.1016/j.xgen.2023.100435

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