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Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development

Major histocompatibility complex (MHC)-Associated Peptide Proteomics (MAPPs) is an ex vivo method used to assess the immunogenicity risk of biotherapeutics. MAPPs can identify potential T-cell epitopes within the biotherapeutic molecule. Using adalimumab treated human monocyte derived dendritic cell...

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Detalles Bibliográficos
Autores principales:	Lee, M. Violet, Saad, Ola M., Wong, Sylvia, LaMar, Jason, Kamen, Lynn, Ordonia, Ben, Melendez, Rachel, Hassanzadeh, Azadeh, Chung, Shan, Kaur, Surinder
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667718/ https://www.ncbi.nlm.nih.gov/pubmed/38022649 http://dx.doi.org/10.3389/fimmu.2023.1295285

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