A Cell‐Penetrant Peptide Disrupting the Transcription Factor CP2c Complexes Induces Cancer‐Specific Synthetic Lethality

Despite advances in precision oncology, cancer remains a global public health issue. In this report, proof‐of‐principle evidence is presented that a cell‐penetrable peptide (ACP52C) dissociates transcription factor CP2c complexes and induces apoptosis in most CP2c oncogene‐addicted cancer cells thro...

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Detalles Bibliográficos
Autores principales: Son, Seung Han, Kim, Min Young, Choi, Sungwoo, Kim, Ji Sook, Lee, Yong Sang, Lee, Sangwon, Lee, Yeon Ju, Lee, Jin Youn, Lee, Seol Eui, Lim, Young Su, Ha, Dae Hyun, Oh, Eonju, Won, Young‐Bin, Ji, Chang‐Jun, Park, Mi Ae, Kim, Boram, Byun, Kyu Tae, Chung, Min Sung, Jeong, Jaemin, Choi, Dongho, Baek, Eun Jung, Cho, Eung‐Ho, Kim, Sang‐Bum, Je, A. Reum, Kweon, Hee‐Seok, Park, Hyun Sook, Park, Dongsun, Bae, June Sung, Jang, Se Jin, Yun, Chae‐Ok, Chae, Ji Hyung, Lee, Jin‐Won, Lee, Su‐Jae, Kim, Chan Gil, Kang, Ho Chul, Uversky, Vladimir N., Kim, Chul Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667816/
https://www.ncbi.nlm.nih.gov/pubmed/37845006
http://dx.doi.org/10.1002/advs.202305096

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