Tumor Microenvironment Responsive CD8(+) T Cells and Myeloid‐Derived Suppressor Cells to Trigger CD73 Inhibitor AB680‐Based Synergistic Therapy for Pancreatic Cancer

CD73 plays a critical role in the pathogenesis and immune escape in pancreatic ductal adenocarcinoma (PDAC). AB680, an exceptionally potent and selective inhibitor of CD73, is administered in an early clinical trial, in conjunction with gemcitabine and anti‐PD‐1 therapy, for the treatment of PDAC. N...

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Detalles Bibliográficos
Autores principales: Chen, Qiangda, Yin, Hanlin, He, Junyi, Xie, Yuqi, Wang, Wenquan, Xu, Huaxiang, Zhang, Lei, Shi, Chenye, Yu, Jun, Wu, Wenchuan, Liu, Liang, Pu, Ning, Lou, Wenhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667825/
https://www.ncbi.nlm.nih.gov/pubmed/37867243
http://dx.doi.org/10.1002/advs.202302498

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