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Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform

Biomimetic viral mineralization improves viral vaccine stability and immunogenicity using inorganic metals such as Ca, Al, or Fe. Mn is a metal found in high concentrations in mammalian tissues; however, under natural or laboratory conditions, Mn mineralization by medical viruses has yet to be estab...

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Autores principales: Shi, Pan‐Deng, Xu, Yan‐Peng, Zhu, Zhu, Zhou, Chao, Wu, Mei, He, Yangzhige, Zhao, Hui, Liu, Liying, Zhao, Linqing, Li, Xiao‐Feng, Qin, Cheng‐Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667830/
https://www.ncbi.nlm.nih.gov/pubmed/37867242
http://dx.doi.org/10.1002/advs.202303615
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author Shi, Pan‐Deng
Xu, Yan‐Peng
Zhu, Zhu
Zhou, Chao
Wu, Mei
He, Yangzhige
Zhao, Hui
Liu, Liying
Zhao, Linqing
Li, Xiao‐Feng
Qin, Cheng‐Feng
author_facet Shi, Pan‐Deng
Xu, Yan‐Peng
Zhu, Zhu
Zhou, Chao
Wu, Mei
He, Yangzhige
Zhao, Hui
Liu, Liying
Zhao, Linqing
Li, Xiao‐Feng
Qin, Cheng‐Feng
author_sort Shi, Pan‐Deng
collection PubMed
description Biomimetic viral mineralization improves viral vaccine stability and immunogenicity using inorganic metals such as Ca, Al, or Fe. Mn is a metal found in high concentrations in mammalian tissues; however, under natural or laboratory conditions, Mn mineralization by medical viruses has yet to be established. Herein, a single IAV particle is successfully encapsulated with manganese phosphate (MnP) under specific conditions using the human influenza A virus (IAV). MnP‐mineralized IAVs (IAV@Mn) exhibited physiochemical and in vitro properties similar to Ca‐mineralized IAVs. In animal models, IAV@Mn shows limited replication in immune‐competent cells and a significant attenuation compared to naïve cells. Moreover, a single‐dose vaccination with IAV@Mn induced robust humoral and cellular immune responses and conferred significant protection against a wild‐type IAV challenge in mice. Thus, Mn mineralization in pathogenic viruses provides a rapid and universal strategy for generating an emergency vaccine in response to emerging viruses.
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spelling pubmed-106678302023-10-22 Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform Shi, Pan‐Deng Xu, Yan‐Peng Zhu, Zhu Zhou, Chao Wu, Mei He, Yangzhige Zhao, Hui Liu, Liying Zhao, Linqing Li, Xiao‐Feng Qin, Cheng‐Feng Adv Sci (Weinh) Research Articles Biomimetic viral mineralization improves viral vaccine stability and immunogenicity using inorganic metals such as Ca, Al, or Fe. Mn is a metal found in high concentrations in mammalian tissues; however, under natural or laboratory conditions, Mn mineralization by medical viruses has yet to be established. Herein, a single IAV particle is successfully encapsulated with manganese phosphate (MnP) under specific conditions using the human influenza A virus (IAV). MnP‐mineralized IAVs (IAV@Mn) exhibited physiochemical and in vitro properties similar to Ca‐mineralized IAVs. In animal models, IAV@Mn shows limited replication in immune‐competent cells and a significant attenuation compared to naïve cells. Moreover, a single‐dose vaccination with IAV@Mn induced robust humoral and cellular immune responses and conferred significant protection against a wild‐type IAV challenge in mice. Thus, Mn mineralization in pathogenic viruses provides a rapid and universal strategy for generating an emergency vaccine in response to emerging viruses. John Wiley and Sons Inc. 2023-10-22 /pmc/articles/PMC10667830/ /pubmed/37867242 http://dx.doi.org/10.1002/advs.202303615 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Shi, Pan‐Deng
Xu, Yan‐Peng
Zhu, Zhu
Zhou, Chao
Wu, Mei
He, Yangzhige
Zhao, Hui
Liu, Liying
Zhao, Linqing
Li, Xiao‐Feng
Qin, Cheng‐Feng
Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform
title Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform
title_full Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform
title_fullStr Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform
title_full_unstemmed Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform
title_short Manganese Mineralization of Pathogenic Viruses as a Universal Vaccine Platform
title_sort manganese mineralization of pathogenic viruses as a universal vaccine platform
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667830/
https://www.ncbi.nlm.nih.gov/pubmed/37867242
http://dx.doi.org/10.1002/advs.202303615
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