Altered binding affinity of SIX1-Q177R correlates with enhanced WNT5A and WNT pathway effector expression in Wilms tumor

Wilms tumors present as an amalgam of varying proportions of tissues located within the developing kidney, one being the nephrogenic blastema comprising multipotent nephron progenitor cells (NPCs). The recurring missense mutation Q177R in NPC transcription factors SIX1 and SIX2 is most correlated wi...

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Detalles Bibliográficos
Autores principales: Stevenson, Matthew J., Phanor, Sabrina K., Patel, Urvi, Gisselbrecht, Stephen S., Bulyk, Martha L., O'Brien, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668032/
https://www.ncbi.nlm.nih.gov/pubmed/37815464
http://dx.doi.org/10.1242/dmm.050208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668032/
https://www.ncbi.nlm.nih.gov/pubmed/37815464
http://dx.doi.org/10.1242/dmm.050208

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