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Pathohistological features of the aging human lacrimal gland

AIM: To assess sex-related differences in the pathohistological features of the human lacrimal gland and to investigate age- and sex-related differences in stereologically measured volume density of the secretory tissue, connective tissue, and fat. METHODS: We performed an observational analysis of...

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Autores principales: Hat, Koraljka, Kaštelan, Snježana, Planinić, Ana, Muller, Danko, Ježek, Davor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668042/
https://www.ncbi.nlm.nih.gov/pubmed/37927184
http://dx.doi.org/10.3325/cmj.2023.64.307
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author Hat, Koraljka
Kaštelan, Snježana
Planinić, Ana
Muller, Danko
Ježek, Davor
author_facet Hat, Koraljka
Kaštelan, Snježana
Planinić, Ana
Muller, Danko
Ježek, Davor
author_sort Hat, Koraljka
collection PubMed
description AIM: To assess sex-related differences in the pathohistological features of the human lacrimal gland and to investigate age- and sex-related differences in stereologically measured volume density of the secretory tissue, connective tissue, and fat. METHODS: We performed an observational analysis of acinar atrophy, periacinar fibrosis, periductal fibrosis, ductal dilation, ductal proliferation, fatty infiltration, and lymphocyte infiltration of hematoxylin and eosin-stained lacrimal gland samples from 81 cornea donors. Stereological analysis of the volume density of the secretory tissue, connective tissue, and fat was performed on samples from 66 donors. RESULTS: Up to 69% of all samples showed degenerative changes. Female samples had a higher frequency of all observed degenerative changes, except ductal dilation. While acinar atrophy was significantly more prevalent in women, ductal dilation was significantly more prevalent in men. Stereological analysis indicated lower portions of acini and higher portions of connective tissue and fat, as well as a more pronounced age-related progression of degenerative changes in female samples. CONCLUSION: Female lacrimal glands are more susceptible to degeneration, and this susceptibility could play an important role in the higher incidence of dry eye disease in older women. A further stereological analysis using more samples from younger age groups is needed to elucidate age-related and sex-related differences in the structure of the human lacrimal gland and their impact on dry eye disease.
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spelling pubmed-106680422023-10-01 Pathohistological features of the aging human lacrimal gland Hat, Koraljka Kaštelan, Snježana Planinić, Ana Muller, Danko Ježek, Davor Croat Med J Research Article AIM: To assess sex-related differences in the pathohistological features of the human lacrimal gland and to investigate age- and sex-related differences in stereologically measured volume density of the secretory tissue, connective tissue, and fat. METHODS: We performed an observational analysis of acinar atrophy, periacinar fibrosis, periductal fibrosis, ductal dilation, ductal proliferation, fatty infiltration, and lymphocyte infiltration of hematoxylin and eosin-stained lacrimal gland samples from 81 cornea donors. Stereological analysis of the volume density of the secretory tissue, connective tissue, and fat was performed on samples from 66 donors. RESULTS: Up to 69% of all samples showed degenerative changes. Female samples had a higher frequency of all observed degenerative changes, except ductal dilation. While acinar atrophy was significantly more prevalent in women, ductal dilation was significantly more prevalent in men. Stereological analysis indicated lower portions of acini and higher portions of connective tissue and fat, as well as a more pronounced age-related progression of degenerative changes in female samples. CONCLUSION: Female lacrimal glands are more susceptible to degeneration, and this susceptibility could play an important role in the higher incidence of dry eye disease in older women. A further stereological analysis using more samples from younger age groups is needed to elucidate age-related and sex-related differences in the structure of the human lacrimal gland and their impact on dry eye disease. Croatian Medical Schools 2023-10 /pmc/articles/PMC10668042/ /pubmed/37927184 http://dx.doi.org/10.3325/cmj.2023.64.307 Text en Copyright © 2023 by the Croatian Medical Journal. All rights reserved. https://creativecommons.org/licenses/by/2.5/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hat, Koraljka
Kaštelan, Snježana
Planinić, Ana
Muller, Danko
Ježek, Davor
Pathohistological features of the aging human lacrimal gland
title Pathohistological features of the aging human lacrimal gland
title_full Pathohistological features of the aging human lacrimal gland
title_fullStr Pathohistological features of the aging human lacrimal gland
title_full_unstemmed Pathohistological features of the aging human lacrimal gland
title_short Pathohistological features of the aging human lacrimal gland
title_sort pathohistological features of the aging human lacrimal gland
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668042/
https://www.ncbi.nlm.nih.gov/pubmed/37927184
http://dx.doi.org/10.3325/cmj.2023.64.307
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