Cargando…

Nrf3 alleviates oxidative stress and promotes the survival of colon cancer cells by activating AKT/BCL-2 signal pathway

Oxidative stress is closely linked to tumor initiation and development, conferring a survival advantage to cancer cells. Therefore, understanding cancer cells’ antioxidant molecular mechanisms is crucial to cancer therapy. In this study, we discovered that H(2)O(2)-induced oxidative stress increased...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Bi-Qing, Chen, Wan-Meng, Chen, Meng-Wei, Chen, Ya-Hui, Tang, Jian-Cai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668112/ https://www.ncbi.nlm.nih.gov/pubmed/38027228 http://dx.doi.org/10.1515/biol-2022-0790

Ejemplares similares

Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-κB/BCL-2 Signaling Pathway In Vitro and In Vivo
por: Cai, Bi-Qing, et al.
Publicado: (2021)

Nrf3 promotes the proliferation and migration of triple‑negative breast cancer by activating PI3K/AKT/mTOR and epithelial‑mesenchymal transition
por: Chen, Wan-Meng, et al.
Publicado: (2023)

Ginsenoside F1 attenuates pirarubicin-induced cardiotoxicity by modulating Nrf2 and AKT/Bcl-2 signaling pathways
por: Zhang, Yang, et al.
Publicado: (2023)

Ischemic Postconditioning Alleviates Intestinal Ischemia-Reperfusion Injury by Enhancing Autophagy and Suppressing Oxidative Stress through the Akt/GSK-3β/Nrf2 Pathway in Mice
por: Chen, Rong, et al.
Publicado: (2020)

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
por: Lu, Meng-Chen, et al.
Publicado: (2016)

CD155 knockdown promotes apoptosis via AKT/Bcl‐2/Bax in colon cancer cells
por: Zheng, Qianqian, et al.
Publicado: (2017)

Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats
por: Zhao, Lingling, et al.
Publicado: (2017)

Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation
por: Wang, Yu-qin, et al.
Publicado: (2018)

Overexpression of Nrf2 promotes colon cancer progression via ERK and AKT signaling pathways
por: Lee, Yoon Jin, et al.
Publicado: (2020)

Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats
por: Zhu, Xiaoyu, et al.
Publicado: (2018)

Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway
por: Yang, Chang-Sheng, et al.
Publicado: (2023)

Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer’s disease
por: Fang, Yinchao, et al.
Publicado: (2020)

Luteolin Alleviates Epithelial-Mesenchymal Transformation Induced by Oxidative Injury in ARPE-19 Cell via Nrf2 and AKT/GSK-3β Pathway
por: Chen, Lan, et al.
Publicado: (2022)

Inhibiting DNA methylation alleviates cigarette smoke extract-induced dysregulation of Bcl-2 and endothelial apoptosis
por: Zeng, Huihui, et al.
Publicado: (2020)

Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation
por: Ge, Zhijuan, et al.
Publicado: (2015)

Fibroblast growth factor 7 alleviates myocardial infarction by improving oxidative stress via PI3Kα/AKT-mediated regulation of Nrf2 and HXK2
por: Mei, Lin, et al.
Publicado: (2022)

FTO Alleviates CdCl(2)-Induced Apoptosis and Oxidative Stress via the AKT/Nrf2 Pathway in Bovine Granulosa Cells
por: Ding, He, et al.
Publicado: (2022)

VKNG-1 Antagonizes ABCG2-Mediated Multidrug Resistance via p-AKT and Bcl-2 Pathway in Colon Cancer: In Vitro and In Vivo Study
por: Narayanan, Silpa, et al.
Publicado: (2021)

Upregulation of microRNA-125b-5p alleviates acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway
por: Tao, Ya-Chao, et al.
Publicado: (2022)

Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis
por: Ren, Chenghao, et al.
Publicado: (2021)

TIGAR promotes growth, survival and metastasis through oxidation resistance and AKT activation in glioblastoma
por: Tang, Zhi, et al.
Publicado: (2019)

BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3‐Akt‐Nrf2 pathway
por: Ding, Peng, et al.
Publicado: (2021)

Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
por: Li, Yuan, et al.
Publicado: (2023)

Tetramethylpyrazine improved the survival of multiterritory perforator flaps by inducing angiogenesis and suppressing apoptosis via the Akt/Nrf2 pathway
por: Qing, LiMing, et al.
Publicado: (2019)

Overexpression of Bcl-2 promotes survival and differentiation of neuroepithelial stem cells after transplantation into rat aganglionic colon
por: Liu, Wei, et al.
Publicado: (2013)

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway
por: Zhang, Qianqian, et al.
Publicado: (2023)

Bcl-2 Is Involved in Cardiac Hypertrophy through PI3K-Akt Pathway
por: Meng, Xianwei, et al.
Publicado: (2021)

Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells
por: Chen, Wenpei, et al.
Publicado: (2021)

Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells
por: Li, Qian, et al.
Publicado: (2021)

Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury
por: Kong, Lingming, et al.
Publicado: (2021)

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways
por: Zhang, Chao, et al.
Publicado: (2016)

Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway
por: Ma, Leyi, et al.
Publicado: (2021)

Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model
por: Zeng, Huihui, et al.
Publicado: (2020)

Oridonin prevents oxidative stress‐induced endothelial injury via promoting Nrf‐2 pathway in ischaemic stroke
por: Li, Lei, et al.
Publicado: (2021)

Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling
por: Wang, Mengyuan, et al.
Publicado: (2023)

BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling
por: Urban, Bettina C, et al.
Publicado: (2016)

Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival
por: Chen, Zhengtai, et al.
Publicado: (2022)

12-Epi-Napelline Inhibits Leukemia Cell Proliferation via the PI3K/AKT Signaling Pathway In Vitro and In Vivo
por: Han, Jia, et al.
Publicado: (2021)

Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2
por: Yin, Bo-Feng, et al.
Publicado: (2022)

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation
por: Lu, Meng-Chen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kt5ftronhpd25j647qr4dilssp