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Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022

BACKGROUND: Preliminary unpublished results of the survey of carbapenem- and/or colistin-resistant Enterobacterales (CCRE survey) showed the expansion of carbapenemase-producing Klebsiella pneumoniae (CPKP) sequence type (ST) 39 in 12 of 15 participating Greek hospitals in 2019. AIM: We conducted a...

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Autores principales: Tryfinopoulou, Kyriaki, Linkevicius, Marius, Pappa, Olga, Alm, Erik, Karadimas, Kleon, Svartström, Olov, Polemis, Michalis, Mellou, Kassiani, Maragkos, Antonis, Brolund, Alma, Fröding, Inga, David, Sophia, Vatopoulos, Alkiviadis, Palm, Daniel, Monnet, Dominique L, Zaoutis, Theoklis, Kohlenberg, Anke, Perivolioti, Efstathia, Andrikogiannopoulos, Petros, Argyropoulou, Athina, Pournaras, Spyros, Vourli, Sofia, Georgiou, Panagiota Christina, Stamoulos, Konstantinos, Christodoulatos, Gerasimos-Socrates, Ntarouis, Iosif, Varveraki, Sofia, Konsolakis, Christos, Panteli, Kalliopi, Zarkotou, Olympia, Rekleiti, Nektaria, Kousouli, Elisavet, Papadogianni, Marina, Zervaki, Kalina, Gavrilidi, Tatiana, Panopoulou, Maria, Lemonakis, Nikolaos, Grapsa, Anastasia, Karampatakis, Theodoros, Kandilioti, Eleni, Gkiti, Tania, Karapavlidou, Paraskevi, Sideris, Christos, Dafa, Evangelia, Gartzonika, Konstantina, Kittas, Christos, Karavasili, Nikoletta, Xytsas, Stelios, Tsilipounidaki, Katerina, Petinaki, Efthymia, Pasxali, Aggeliki, Sorovou, Glykeria, Krikoni, Efrosini, Bartzavali, Christina, Kolonitsiou, Fevronia, Paliogianni, Fotini, Kaminioti, Christina, Mparka, Christina, Petropoulou, Dimitra, Giannopoulou, Panagiota, Charalampaki, Nikoletta, Kappou, Penelope
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668257/
https://www.ncbi.nlm.nih.gov/pubmed/37997662
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.47.2300571
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author Tryfinopoulou, Kyriaki
Linkevicius, Marius
Pappa, Olga
Alm, Erik
Karadimas, Kleon
Svartström, Olov
Polemis, Michalis
Mellou, Kassiani
Maragkos, Antonis
Brolund, Alma
Fröding, Inga
David, Sophia
Vatopoulos, Alkiviadis
Palm, Daniel
Monnet, Dominique L
Zaoutis, Theoklis
Kohlenberg, Anke
Perivolioti, Efstathia
Andrikogiannopoulos, Petros
Argyropoulou, Athina
Pournaras, Spyros
Vourli, Sofia
Georgiou, Panagiota Christina
Stamoulos, Konstantinos
Christodoulatos, Gerasimos-Socrates
Ntarouis, Iosif
Varveraki, Sofia
Konsolakis, Christos
Panteli, Kalliopi
Zarkotou, Olympia
Rekleiti, Nektaria
Kousouli, Elisavet
Papadogianni, Marina
Zervaki, Kalina
Gavrilidi, Tatiana
Panopoulou, Maria
Lemonakis, Nikolaos
Grapsa, Anastasia
Karampatakis, Theodoros
Kandilioti, Eleni
Gkiti, Tania
Karapavlidou, Paraskevi
Sideris, Christos
Dafa, Evangelia
Gartzonika, Konstantina
Kittas, Christos
Karavasili, Nikoletta
Xytsas, Stelios
Tsilipounidaki, Katerina
Petinaki, Efthymia
Pasxali, Aggeliki
Sorovou, Glykeria
Krikoni, Efrosini
Bartzavali, Christina
Kolonitsiou, Fevronia
Paliogianni, Fotini
Kaminioti, Christina
Mparka, Christina
Petropoulou, Dimitra
Giannopoulou, Panagiota
Charalampaki, Nikoletta
Kappou, Penelope
author_facet Tryfinopoulou, Kyriaki
Linkevicius, Marius
Pappa, Olga
Alm, Erik
Karadimas, Kleon
Svartström, Olov
Polemis, Michalis
Mellou, Kassiani
Maragkos, Antonis
Brolund, Alma
Fröding, Inga
David, Sophia
Vatopoulos, Alkiviadis
Palm, Daniel
Monnet, Dominique L
Zaoutis, Theoklis
Kohlenberg, Anke
Perivolioti, Efstathia
Andrikogiannopoulos, Petros
Argyropoulou, Athina
Pournaras, Spyros
Vourli, Sofia
Georgiou, Panagiota Christina
Stamoulos, Konstantinos
Christodoulatos, Gerasimos-Socrates
Ntarouis, Iosif
Varveraki, Sofia
Konsolakis, Christos
Panteli, Kalliopi
Zarkotou, Olympia
Rekleiti, Nektaria
Kousouli, Elisavet
Papadogianni, Marina
Zervaki, Kalina
Gavrilidi, Tatiana
Panopoulou, Maria
Lemonakis, Nikolaos
Grapsa, Anastasia
Karampatakis, Theodoros
Kandilioti, Eleni
Gkiti, Tania
Karapavlidou, Paraskevi
Sideris, Christos
Dafa, Evangelia
Gartzonika, Konstantina
Kittas, Christos
Karavasili, Nikoletta
Xytsas, Stelios
Tsilipounidaki, Katerina
Petinaki, Efthymia
Pasxali, Aggeliki
Sorovou, Glykeria
Krikoni, Efrosini
Bartzavali, Christina
Kolonitsiou, Fevronia
Paliogianni, Fotini
Kaminioti, Christina
Mparka, Christina
Petropoulou, Dimitra
Giannopoulou, Panagiota
Charalampaki, Nikoletta
Kappou, Penelope
author_sort Tryfinopoulou, Kyriaki
collection PubMed
description BACKGROUND: Preliminary unpublished results of the survey of carbapenem- and/or colistin-resistant Enterobacterales (CCRE survey) showed the expansion of carbapenemase-producing Klebsiella pneumoniae (CPKP) sequence type (ST) 39 in 12 of 15 participating Greek hospitals in 2019. AIM: We conducted a rapid survey to determine the extent of spread of CPKP high-risk clones in Greek hospitals in 2022 and compare the distribution of circulating CPKP clones in these hospitals since 2013. METHODS: We analysed whole genome sequences and epidemiological data of 310 K. pneumoniae isolates that were carbapenem-resistant or ‘susceptible, increased exposure’ from Greek hospitals that participated in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE, 2013–2014), in the CCRE survey (2019) and in a national follow-up survey (2022) including, for the latter, an estimation of transmission events. RESULTS: Five K. pneumoniae STs including ST258/512 (n = 101 isolates), ST11 (n = 93), ST39 (n = 56), ST147 (n = 21) and ST323 (n = 13) accounted for more than 90% of CPKP isolates in the dataset. While ST11, ST147 and ST258/512 have been detected in participating hospitals since 2013 and 2014, KPC-2-producing ST39 and ST323 emerged in 2019 and 2022, respectively. Based on the defined genetic relatedness cut-off, 44 within-hospital transmission events were identified in the 2022 survey dataset, with 12 of 15 participating hospitals having at least one within-hospital transmission event. CONCLUSION: The recent emergence and rapid spread of new high-risk K. pneumoniae clones in the Greek healthcare system related to within-hospital transmission is of concern and highlights the need for molecular surveillance and enhanced infection prevention and control measures.
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spelling pubmed-106682572023-11-23 Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022 Tryfinopoulou, Kyriaki Linkevicius, Marius Pappa, Olga Alm, Erik Karadimas, Kleon Svartström, Olov Polemis, Michalis Mellou, Kassiani Maragkos, Antonis Brolund, Alma Fröding, Inga David, Sophia Vatopoulos, Alkiviadis Palm, Daniel Monnet, Dominique L Zaoutis, Theoklis Kohlenberg, Anke Perivolioti, Efstathia Andrikogiannopoulos, Petros Argyropoulou, Athina Pournaras, Spyros Vourli, Sofia Georgiou, Panagiota Christina Stamoulos, Konstantinos Christodoulatos, Gerasimos-Socrates Ntarouis, Iosif Varveraki, Sofia Konsolakis, Christos Panteli, Kalliopi Zarkotou, Olympia Rekleiti, Nektaria Kousouli, Elisavet Papadogianni, Marina Zervaki, Kalina Gavrilidi, Tatiana Panopoulou, Maria Lemonakis, Nikolaos Grapsa, Anastasia Karampatakis, Theodoros Kandilioti, Eleni Gkiti, Tania Karapavlidou, Paraskevi Sideris, Christos Dafa, Evangelia Gartzonika, Konstantina Kittas, Christos Karavasili, Nikoletta Xytsas, Stelios Tsilipounidaki, Katerina Petinaki, Efthymia Pasxali, Aggeliki Sorovou, Glykeria Krikoni, Efrosini Bartzavali, Christina Kolonitsiou, Fevronia Paliogianni, Fotini Kaminioti, Christina Mparka, Christina Petropoulou, Dimitra Giannopoulou, Panagiota Charalampaki, Nikoletta Kappou, Penelope Euro Surveill Surveillance BACKGROUND: Preliminary unpublished results of the survey of carbapenem- and/or colistin-resistant Enterobacterales (CCRE survey) showed the expansion of carbapenemase-producing Klebsiella pneumoniae (CPKP) sequence type (ST) 39 in 12 of 15 participating Greek hospitals in 2019. AIM: We conducted a rapid survey to determine the extent of spread of CPKP high-risk clones in Greek hospitals in 2022 and compare the distribution of circulating CPKP clones in these hospitals since 2013. METHODS: We analysed whole genome sequences and epidemiological data of 310 K. pneumoniae isolates that were carbapenem-resistant or ‘susceptible, increased exposure’ from Greek hospitals that participated in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE, 2013–2014), in the CCRE survey (2019) and in a national follow-up survey (2022) including, for the latter, an estimation of transmission events. RESULTS: Five K. pneumoniae STs including ST258/512 (n = 101 isolates), ST11 (n = 93), ST39 (n = 56), ST147 (n = 21) and ST323 (n = 13) accounted for more than 90% of CPKP isolates in the dataset. While ST11, ST147 and ST258/512 have been detected in participating hospitals since 2013 and 2014, KPC-2-producing ST39 and ST323 emerged in 2019 and 2022, respectively. Based on the defined genetic relatedness cut-off, 44 within-hospital transmission events were identified in the 2022 survey dataset, with 12 of 15 participating hospitals having at least one within-hospital transmission event. CONCLUSION: The recent emergence and rapid spread of new high-risk K. pneumoniae clones in the Greek healthcare system related to within-hospital transmission is of concern and highlights the need for molecular surveillance and enhanced infection prevention and control measures. European Centre for Disease Prevention and Control (ECDC) 2023-11-23 /pmc/articles/PMC10668257/ /pubmed/37997662 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.47.2300571 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance
Tryfinopoulou, Kyriaki
Linkevicius, Marius
Pappa, Olga
Alm, Erik
Karadimas, Kleon
Svartström, Olov
Polemis, Michalis
Mellou, Kassiani
Maragkos, Antonis
Brolund, Alma
Fröding, Inga
David, Sophia
Vatopoulos, Alkiviadis
Palm, Daniel
Monnet, Dominique L
Zaoutis, Theoklis
Kohlenberg, Anke
Perivolioti, Efstathia
Andrikogiannopoulos, Petros
Argyropoulou, Athina
Pournaras, Spyros
Vourli, Sofia
Georgiou, Panagiota Christina
Stamoulos, Konstantinos
Christodoulatos, Gerasimos-Socrates
Ntarouis, Iosif
Varveraki, Sofia
Konsolakis, Christos
Panteli, Kalliopi
Zarkotou, Olympia
Rekleiti, Nektaria
Kousouli, Elisavet
Papadogianni, Marina
Zervaki, Kalina
Gavrilidi, Tatiana
Panopoulou, Maria
Lemonakis, Nikolaos
Grapsa, Anastasia
Karampatakis, Theodoros
Kandilioti, Eleni
Gkiti, Tania
Karapavlidou, Paraskevi
Sideris, Christos
Dafa, Evangelia
Gartzonika, Konstantina
Kittas, Christos
Karavasili, Nikoletta
Xytsas, Stelios
Tsilipounidaki, Katerina
Petinaki, Efthymia
Pasxali, Aggeliki
Sorovou, Glykeria
Krikoni, Efrosini
Bartzavali, Christina
Kolonitsiou, Fevronia
Paliogianni, Fotini
Kaminioti, Christina
Mparka, Christina
Petropoulou, Dimitra
Giannopoulou, Panagiota
Charalampaki, Nikoletta
Kappou, Penelope
Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022
title Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022
title_full Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022
title_fullStr Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022
title_full_unstemmed Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022
title_short Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022
title_sort emergence and persistent spread of carbapenemase-producing klebsiella pneumoniae high-risk clones in greek hospitals, 2013 to 2022
topic Surveillance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668257/
https://www.ncbi.nlm.nih.gov/pubmed/37997662
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.47.2300571
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