Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1

Chronic activation and dysfunction of microglia have been implicated in the pathogenesis and progression of many neurodegenerative disorders, including Huntington’s disease (HD). HD is a genetic condition caused by a mutation that affects the folding and function of huntingtin (HTT). Signs of microg...

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Detalles Bibliográficos
Autores principales: Steinberg, Noam, Galleguillos, Danny, Zaidi, Asifa, Horkey, Melanie, Sipione, Simonetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668379/
https://www.ncbi.nlm.nih.gov/pubmed/37996924
http://dx.doi.org/10.1186/s12974-023-02963-y

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