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Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration
PURPOSE: In a cohort, observational prospective trial, we assessed the long-term dynamics of sleep-disordered breathing in patients with resistant hypertension after renal denervation and their association with blood pressure change at remote follow-up. MATERIALS AND METHODS: Twenty-eight patients w...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668416/ https://www.ncbi.nlm.nih.gov/pubmed/37996833 http://dx.doi.org/10.1186/s12890-023-02757-1 |
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author | Korostovtseva, Lyudmila S. Ionov, Mikhail V. Shcherbakova, Elizaveta A. Bochkarev, Mikhail V. Emelyanov, Igor V. Yudina, Yulia S. Mironova, Svetlana A. Zverev, Dmitry A. Lebedev, Dmitry S. Vakhrushev, Aleksandr D. Avdonina, Natalia G. Zvartau, Nadezhda E. Mikhaylov, Evgeny N. Sviryaev, Yurii V. Konradi, Aleksandra O. |
author_facet | Korostovtseva, Lyudmila S. Ionov, Mikhail V. Shcherbakova, Elizaveta A. Bochkarev, Mikhail V. Emelyanov, Igor V. Yudina, Yulia S. Mironova, Svetlana A. Zverev, Dmitry A. Lebedev, Dmitry S. Vakhrushev, Aleksandr D. Avdonina, Natalia G. Zvartau, Nadezhda E. Mikhaylov, Evgeny N. Sviryaev, Yurii V. Konradi, Aleksandra O. |
author_sort | Korostovtseva, Lyudmila S. |
collection | PubMed |
description | PURPOSE: In a cohort, observational prospective trial, we assessed the long-term dynamics of sleep-disordered breathing in patients with resistant hypertension after renal denervation and their association with blood pressure change at remote follow-up. MATERIALS AND METHODS: Twenty-eight patients with stable hypertension who were recruited for endovascular radiofrequency renal denervation in 2012–2019 and had valid both baseline and follow-up sleep study, were included in the analysis. All patients underwent physical examination, anthropometry, office and ambulatory blood pressure measurements, blood and urine tests, kidney visualization, and full polysomnography before and within 12–36 months after renal denervation. RESULTS: The average follow-up comprised 30.1 ± 8.4 months. At long-term follow-up, no significant changes in creatinine level, estimated glomerular filtration rate, body mass index were registered. There was a significant increase in sleep apnea severity indices: the mean change in apnea-hypopnea index comprised 9.0(-21.1;25.2) episodes/h, in oxygen desaturation index 6.5(-16.8;35.9) episodes/h, in the average SpO(2) -1.7(-5.6;1.9)%. Over 12-month follow-up, there were no significant differences in blood pressure response in patients with and without sleep apnea. The baseline apnea-hypopnea and oxygen desaturation indices and the mean SpO(2) were associated with the circadian blood pressure profile at follow-up, but did not correlate with the blood pressure response. CONCLUSIONS: Although the severity of sleep apnea worsens at > 12 months follow-up after renal denervation, this is not associated with hypertension exaggeration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-023-02757-1. |
format | Online Article Text |
id | pubmed-10668416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106684162023-11-23 Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration Korostovtseva, Lyudmila S. Ionov, Mikhail V. Shcherbakova, Elizaveta A. Bochkarev, Mikhail V. Emelyanov, Igor V. Yudina, Yulia S. Mironova, Svetlana A. Zverev, Dmitry A. Lebedev, Dmitry S. Vakhrushev, Aleksandr D. Avdonina, Natalia G. Zvartau, Nadezhda E. Mikhaylov, Evgeny N. Sviryaev, Yurii V. Konradi, Aleksandra O. BMC Pulm Med Research PURPOSE: In a cohort, observational prospective trial, we assessed the long-term dynamics of sleep-disordered breathing in patients with resistant hypertension after renal denervation and their association with blood pressure change at remote follow-up. MATERIALS AND METHODS: Twenty-eight patients with stable hypertension who were recruited for endovascular radiofrequency renal denervation in 2012–2019 and had valid both baseline and follow-up sleep study, were included in the analysis. All patients underwent physical examination, anthropometry, office and ambulatory blood pressure measurements, blood and urine tests, kidney visualization, and full polysomnography before and within 12–36 months after renal denervation. RESULTS: The average follow-up comprised 30.1 ± 8.4 months. At long-term follow-up, no significant changes in creatinine level, estimated glomerular filtration rate, body mass index were registered. There was a significant increase in sleep apnea severity indices: the mean change in apnea-hypopnea index comprised 9.0(-21.1;25.2) episodes/h, in oxygen desaturation index 6.5(-16.8;35.9) episodes/h, in the average SpO(2) -1.7(-5.6;1.9)%. Over 12-month follow-up, there were no significant differences in blood pressure response in patients with and without sleep apnea. The baseline apnea-hypopnea and oxygen desaturation indices and the mean SpO(2) were associated with the circadian blood pressure profile at follow-up, but did not correlate with the blood pressure response. CONCLUSIONS: Although the severity of sleep apnea worsens at > 12 months follow-up after renal denervation, this is not associated with hypertension exaggeration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-023-02757-1. BioMed Central 2023-11-23 /pmc/articles/PMC10668416/ /pubmed/37996833 http://dx.doi.org/10.1186/s12890-023-02757-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Korostovtseva, Lyudmila S. Ionov, Mikhail V. Shcherbakova, Elizaveta A. Bochkarev, Mikhail V. Emelyanov, Igor V. Yudina, Yulia S. Mironova, Svetlana A. Zverev, Dmitry A. Lebedev, Dmitry S. Vakhrushev, Aleksandr D. Avdonina, Natalia G. Zvartau, Nadezhda E. Mikhaylov, Evgeny N. Sviryaev, Yurii V. Konradi, Aleksandra O. Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration |
title | Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration |
title_full | Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration |
title_fullStr | Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration |
title_full_unstemmed | Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration |
title_short | Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration |
title_sort | progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668416/ https://www.ncbi.nlm.nih.gov/pubmed/37996833 http://dx.doi.org/10.1186/s12890-023-02757-1 |
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