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Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Being stimulated by the chemokine CXCL12, the CXCR4 / CXCR7 cascade is involved in tumor proliferation, migration, and metastasis. The interaction between CXCL12, secreted by cells from the microenvironment, and its receptors is complex and has been ascribed to promote chemotherapy resistance. Howev...
Autores principales: | Wakileh, Gamal A., Bierholz, Philipp, Kotthoff, Mara, Skowron, Margaretha A., Bremmer, Felix, Stephan, Alexa, Anbuhl, Stephanie M., Heukers, Raimond, Smit, Martine J., Ströbel, Philipp, Nettersheim, Daniel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668499/ https://www.ncbi.nlm.nih.gov/pubmed/37996954 http://dx.doi.org/10.1186/s40164-023-00460-9 |
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