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Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital

A pressure ulcer is defined as a skin lesion of ischemic origin, a condition that contributes to morbidity and mortality in patients with spinal cord injuries. The most common complication of ulcers is a bacterial infection. Antimicrobial therapy should be selected with caution for spinal cord injur...

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Autores principales: Binsuwaidan, Reem, Khan, Mohammad Aatif, Alzahrani, Raghad H., Aldusaymani, Aljoharah M., Almallouhi, Noura M., Alsabti, Alhanouf S., Ali, Sajjad, Khan, Omar Sufyan, Youssef, Amira M., Alnajjar, Lina I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668744/
https://www.ncbi.nlm.nih.gov/pubmed/37998789
http://dx.doi.org/10.3390/antibiotics12111587
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author Binsuwaidan, Reem
Khan, Mohammad Aatif
Alzahrani, Raghad H.
Aldusaymani, Aljoharah M.
Almallouhi, Noura M.
Alsabti, Alhanouf S.
Ali, Sajjad
Khan, Omar Sufyan
Youssef, Amira M.
Alnajjar, Lina I.
author_facet Binsuwaidan, Reem
Khan, Mohammad Aatif
Alzahrani, Raghad H.
Aldusaymani, Aljoharah M.
Almallouhi, Noura M.
Alsabti, Alhanouf S.
Ali, Sajjad
Khan, Omar Sufyan
Youssef, Amira M.
Alnajjar, Lina I.
author_sort Binsuwaidan, Reem
collection PubMed
description A pressure ulcer is defined as a skin lesion of ischemic origin, a condition that contributes to morbidity and mortality in patients with spinal cord injuries. The most common complication of ulcers is a bacterial infection. Antimicrobial therapy should be selected with caution for spinal cord injury patients since they have a high risk of developing multidrug-resistant (MDR) infections. The aim of this study was to determine the prevalence of different bacterial pathogens in patients with pressure ulcers admitted with spinal cord injuries. This was a retrospective single-center study that included adult patients aged 18 years and above, admitted with chronic pressure wounds after a spinal cord injury requiring hospitalization between 2015 and 2021. A total of 203 spinal cord injury patients with pressure ulcers were included in the study. Ulcers were commonly infected by Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, and they were mostly located in the sacral and gluteal areas. More than half of the bacteria isolated from patients were sensitive to commonly tested antibiotics, while 10% were either MDR- or pan-drug-resistant organisms. Of the MDR bacterial isolates, 25.61% were methicillin-resistant S. aureus, and 17.73% were extended-spectrum beta-lactamase Enterobacteriaceae. The most prevalent bacteria in pressure ulcers of spinal cord injury patients were S. aureus. Other antibiotic-resistant organisms were also isolated from the wounds.
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spelling pubmed-106687442023-11-02 Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital Binsuwaidan, Reem Khan, Mohammad Aatif Alzahrani, Raghad H. Aldusaymani, Aljoharah M. Almallouhi, Noura M. Alsabti, Alhanouf S. Ali, Sajjad Khan, Omar Sufyan Youssef, Amira M. Alnajjar, Lina I. Antibiotics (Basel) Article A pressure ulcer is defined as a skin lesion of ischemic origin, a condition that contributes to morbidity and mortality in patients with spinal cord injuries. The most common complication of ulcers is a bacterial infection. Antimicrobial therapy should be selected with caution for spinal cord injury patients since they have a high risk of developing multidrug-resistant (MDR) infections. The aim of this study was to determine the prevalence of different bacterial pathogens in patients with pressure ulcers admitted with spinal cord injuries. This was a retrospective single-center study that included adult patients aged 18 years and above, admitted with chronic pressure wounds after a spinal cord injury requiring hospitalization between 2015 and 2021. A total of 203 spinal cord injury patients with pressure ulcers were included in the study. Ulcers were commonly infected by Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, and they were mostly located in the sacral and gluteal areas. More than half of the bacteria isolated from patients were sensitive to commonly tested antibiotics, while 10% were either MDR- or pan-drug-resistant organisms. Of the MDR bacterial isolates, 25.61% were methicillin-resistant S. aureus, and 17.73% were extended-spectrum beta-lactamase Enterobacteriaceae. The most prevalent bacteria in pressure ulcers of spinal cord injury patients were S. aureus. Other antibiotic-resistant organisms were also isolated from the wounds. MDPI 2023-11-02 /pmc/articles/PMC10668744/ /pubmed/37998789 http://dx.doi.org/10.3390/antibiotics12111587 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Binsuwaidan, Reem
Khan, Mohammad Aatif
Alzahrani, Raghad H.
Aldusaymani, Aljoharah M.
Almallouhi, Noura M.
Alsabti, Alhanouf S.
Ali, Sajjad
Khan, Omar Sufyan
Youssef, Amira M.
Alnajjar, Lina I.
Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital
title Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital
title_full Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital
title_fullStr Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital
title_full_unstemmed Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital
title_short Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital
title_sort prevalence of multidrug-resistant and esbl-producing bacterial pathogens in patients with chronic wound infections and spinal cord injury admitted to a tertiary care rehabilitation hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668744/
https://www.ncbi.nlm.nih.gov/pubmed/37998789
http://dx.doi.org/10.3390/antibiotics12111587
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