A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer

Several studies in the last few years have determined that, in contrast to the prevailing dogma that drug resistance is simply due to Darwinian evolution—the selection of mutant clones in response to drug treatment—non-genetic changes can also lead to drug resistance whereby tolerant, reversible phe...

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Detalles Bibliográficos
Autores principales: Kulkarni, Prakash, Mohanty, Atish, Ramisetty, Sravani, Duvivier, Herbert, Khan, Ajaz, Shrestha, Sagun, Tan, Tingting, Merla, Amartej, El-Hajjaoui, Michelle, Malhotra, Jyoti, Singhal, Sharad, Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668935/
https://www.ncbi.nlm.nih.gov/pubmed/38002269
http://dx.doi.org/10.3390/biom13111587

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