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Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats

SIMPLE SUMMARY: The search for regenerative treatments is one of the main objectives of researchers to find effective ways of repairing bone defects and forming areas of bone of sufficient quality and quantity which can receive osseointegrated implants to reconstruct areas affected by periodontal le...

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Autores principales: Frigério, Paula Buzo, Quirino, Lilian Caldas, Gabrielli, Marisa Aparecida Cabrini, Carvalho, Pedro Henrique de Azambuja, Garcia Júnior, Idelmo Rangel, Pereira-Filho, Valfrido Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668970/
https://www.ncbi.nlm.nih.gov/pubmed/37998016
http://dx.doi.org/10.3390/biology12111417
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author Frigério, Paula Buzo
Quirino, Lilian Caldas
Gabrielli, Marisa Aparecida Cabrini
Carvalho, Pedro Henrique de Azambuja
Garcia Júnior, Idelmo Rangel
Pereira-Filho, Valfrido Antonio
author_facet Frigério, Paula Buzo
Quirino, Lilian Caldas
Gabrielli, Marisa Aparecida Cabrini
Carvalho, Pedro Henrique de Azambuja
Garcia Júnior, Idelmo Rangel
Pereira-Filho, Valfrido Antonio
author_sort Frigério, Paula Buzo
collection PubMed
description SIMPLE SUMMARY: The search for regenerative treatments is one of the main objectives of researchers to find effective ways of repairing bone defects and forming areas of bone of sufficient quality and quantity which can receive osseointegrated implants to reconstruct areas affected by periodontal lesions and/or systemic diseases. Biphasic bioceramics are synthetic bone substitutes made of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). These materials have osteoconductive properties and are chemically and structurally similar to bone matrix, providing better safety and predictability during guided bone regeneration. This study aimed to evaluate the bone repair process using a new biphasic bioceramic (Plenum(®) Oss(hp)—70HA: 30β-TCP) compared to a synthetic graft (Straumann(®) BoneCeramic™) in a critical defect in the calvaria of rats. It was observed that the new Plenum(®) Oss(hp) bioceramic, in the rat calvaria model, offered excellent safety and surgical predictability, being efficient in the bone repair process. Plenum(®) Oss(hp) behaved similarly to the commercial control (BoneCeramic™) and can be considered an effective option as a synthetic bone substitute in the dental clinic, especially for implantology. ABSTRACT: (1) Background: Biphasic bioceramics are synthetic bone substitutes that provide greater safety and better predictability in guided bone regeneration. This study aimed to evaluate the bone repair process using a new biphasic bioceramic of synthetic origin (Plenum(®) Oss(hp)—70HA: 30β-TCP) in critical calvarial defects. (2) Methods: seventy-four defects were created in rat calvaria and divided into two groups—Plenum(®) Oss(hp) (PO), right side, and Straumann(®) BoneCeramic™ (BC), left side. Euthanasia was performed at 7, 15, 30, and 60 days after surgery. (3) Results: Lower gene expression was observed for runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF) and higher expression for Integrin Binding Sialoprotein (IBSP). The results correlated with moderate immunolabeling for osteocalcin (OCN) and slight immunolabeling for osteopontin (OPN) in the PO group. Histometry showed a greater amount of biomaterial remaining in the PO group at 60 days. The microtomographic analysis showed a lower density of bone connectivity and a greater thickness of the trabeculae for the remnants of the PO group. (4) Conclusions: the Plenum(®) Oss(hp) showed no differences compared to BoneCeramic™ and is therefore considered an effective option as a synthetic bone substitute in bone regeneration.
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spelling pubmed-106689702023-11-10 Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats Frigério, Paula Buzo Quirino, Lilian Caldas Gabrielli, Marisa Aparecida Cabrini Carvalho, Pedro Henrique de Azambuja Garcia Júnior, Idelmo Rangel Pereira-Filho, Valfrido Antonio Biology (Basel) Article SIMPLE SUMMARY: The search for regenerative treatments is one of the main objectives of researchers to find effective ways of repairing bone defects and forming areas of bone of sufficient quality and quantity which can receive osseointegrated implants to reconstruct areas affected by periodontal lesions and/or systemic diseases. Biphasic bioceramics are synthetic bone substitutes made of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). These materials have osteoconductive properties and are chemically and structurally similar to bone matrix, providing better safety and predictability during guided bone regeneration. This study aimed to evaluate the bone repair process using a new biphasic bioceramic (Plenum(®) Oss(hp)—70HA: 30β-TCP) compared to a synthetic graft (Straumann(®) BoneCeramic™) in a critical defect in the calvaria of rats. It was observed that the new Plenum(®) Oss(hp) bioceramic, in the rat calvaria model, offered excellent safety and surgical predictability, being efficient in the bone repair process. Plenum(®) Oss(hp) behaved similarly to the commercial control (BoneCeramic™) and can be considered an effective option as a synthetic bone substitute in the dental clinic, especially for implantology. ABSTRACT: (1) Background: Biphasic bioceramics are synthetic bone substitutes that provide greater safety and better predictability in guided bone regeneration. This study aimed to evaluate the bone repair process using a new biphasic bioceramic of synthetic origin (Plenum(®) Oss(hp)—70HA: 30β-TCP) in critical calvarial defects. (2) Methods: seventy-four defects were created in rat calvaria and divided into two groups—Plenum(®) Oss(hp) (PO), right side, and Straumann(®) BoneCeramic™ (BC), left side. Euthanasia was performed at 7, 15, 30, and 60 days after surgery. (3) Results: Lower gene expression was observed for runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF) and higher expression for Integrin Binding Sialoprotein (IBSP). The results correlated with moderate immunolabeling for osteocalcin (OCN) and slight immunolabeling for osteopontin (OPN) in the PO group. Histometry showed a greater amount of biomaterial remaining in the PO group at 60 days. The microtomographic analysis showed a lower density of bone connectivity and a greater thickness of the trabeculae for the remnants of the PO group. (4) Conclusions: the Plenum(®) Oss(hp) showed no differences compared to BoneCeramic™ and is therefore considered an effective option as a synthetic bone substitute in bone regeneration. MDPI 2023-11-10 /pmc/articles/PMC10668970/ /pubmed/37998016 http://dx.doi.org/10.3390/biology12111417 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Frigério, Paula Buzo
Quirino, Lilian Caldas
Gabrielli, Marisa Aparecida Cabrini
Carvalho, Pedro Henrique de Azambuja
Garcia Júnior, Idelmo Rangel
Pereira-Filho, Valfrido Antonio
Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats
title Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats
title_full Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats
title_fullStr Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats
title_full_unstemmed Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats
title_short Evaluation of Bone Repair Using a New Biphasic Synthetic Bioceramic (Plenum(®) Oss(hp)) in Critical Calvaria Defect in Rats
title_sort evaluation of bone repair using a new biphasic synthetic bioceramic (plenum(®) oss(hp)) in critical calvaria defect in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668970/
https://www.ncbi.nlm.nih.gov/pubmed/37998016
http://dx.doi.org/10.3390/biology12111417
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