Cargando…

Combination Therapy of RAS Inhibition and SGLT2 Inhibitors Decreases Levels of Endotrophin in Persons with Type 2 Diabetes

We investigated for the first time the effect of combination therapy of renin–angiotensin system inhibition (RASi) and sodium–glucose co-transporter-2 inhibitors (SGLT2is) on endotrophin (ETP), a pro-fibrotic signaling molecule reflecting collagen type VI formation, measured in the plasma of persons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Møller, Alexandra Louise, Thöni, Stefanie, Keller, Felix, Sharifli, Samir, Rasmussen, Daniel Guldager Kring, Genovese, Federica, Karsdal, Morten Asser, Mayer, Gert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669010/ https://www.ncbi.nlm.nih.gov/pubmed/38002084 http://dx.doi.org/10.3390/biomedicines11113084

Ejemplares similares

Urinary endotrophin predicts disease progression in patients with chronic kidney disease
por: Rasmussen, Daniel Guldager Kring, et al.
Publicado: (2017)

Endotrophin as a risk marker of mortality and kidney complications in a type 1 diabetes cohort
por: Møller, Alexandra Louise, et al.
Publicado: (2023)

Endotrophin is a risk marker of complications in CANagliflozin cardioVascular Assessment Study (CANVAS): a randomized controlled trial
por: Rasmussen, Daniel Guldager Kring, et al.
Publicado: (2022)

Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients
por: Sparding, Nadja, et al.
Publicado: (2023)

Endotrophin, a collagen type VI-derived matrikine, reflects the degree of renal fibrosis in patients with IgA nephropathy and in patients with ANCA-associated vasculitis
por: Sparding, Nadja, et al.
Publicado: (2021)

Development of a Novel Enzyme-Linked Immunosorbent Assay Targeting a Neo-Epitope Generated by Cathepsin-Mediated Turnover of Type III Collagen and Its Application in Chronic Obstructive Pulmonary Disease
por: Rasmussen, Daniel Guldager Kring, et al.
Publicado: (2017)

Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging
por: Nielsen, Per Mose, et al.
Publicado: (2020)

Collagen turnover profiles in chronic kidney disease
por: Rasmussen, Daniel Guldager Kring, et al.
Publicado: (2019)

Urinary collagen degradation products as early markers of progressive renal fibrosis
por: Hijmans, Ryanne S., et al.
Publicado: (2017)

Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
por: Reese-Petersen, Alexander L., et al.
Publicado: (2023)

Imbalanced turnover of collagen type III is associated with disease progression and mortality in high-risk chronic kidney disease patients
por: Genovese, Federica, et al.
Publicado: (2020)

Pretransplant endotrophin predicts delayed graft function after kidney transplantation
por: Tepel, Martin, et al.
Publicado: (2022)

Serum endotrophin, a type VI collagen cleavage product, is associated with increased mortality in chronic kidney disease
por: Fenton, Anthony, et al.
Publicado: (2017)

Endotrophin, a pro-peptide of Type VI collagen, is a biomarker of survival in cirrhotic patients with hepatocellular carcinoma
por: Leeming, Diana Julie, et al.
Publicado: (2020)

The novel collagen matrikine, endotrophin, is associated with mortality and cardiovascular events in patients with atherosclerosis
por: Holm Nielsen, S., et al.
Publicado: (2021)

Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women
por: Staunstrup, Line Mærsk, et al.
Publicado: (2021)

Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTRs: results from two prospective cohort studies
por: Kremer, Daan, et al.
Publicado: (2022)

A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease
por: Holm Nielsen, Signe, et al.
Publicado: (2018)

The Mechanism for Adipose Endotrophin Production
por: Lee, Yun Sok
Publicado: (2022)

A Fragment of Collagen Type VI alpha-3 chain is Elevated in Serum from Patients with Gastrointestinal Disorders
por: Holm Nielsen, Signe, et al.
Publicado: (2020)

Endotrophin and C6Ma3, serological biomarkers of type VI collagen remodelling, reflect endoscopic and clinical disease activity in IBD
por: Lindholm, Majken, et al.
Publicado: (2021)

Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV
por: Dold, Leona, et al.
Publicado: (2023)

Endotrophin – Linking Obesity with Aggressive Tumor Growth
por: Park, Jiyoung, et al.
Publicado: (2012)

The impact of endotrophin on the progression of chronic liver disease
por: Kim, Min, et al.
Publicado: (2020)

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort
por: Rønnow, Sarah R., et al.
Publicado: (2020)

Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis
por: Thöni, Stefanie, et al.
Publicado: (2022)

Correlation of glycemic regulation and endotrophin in patients with type 2 Diabetes; pilot study
por: Yoldemir, Sengul Aydin, et al.
Publicado: (2021)

Endotrophin: Nominated for best supporting actor in the fibro-inflammatory saga
por: Scherer, Philipp E., et al.
Publicado: (2021)

The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
por: Genovese, Federica, et al.
Publicado: (2014)

SGLT2is vs. GLP1RAs Reduce Cardiovascular and All-Cause Mortality
por: Qiu, Mei, et al.
Publicado: (2021)

The cardiovascular effects of SGLT2 inhibitors, RAS inhibitors, and ARN inhibitors in heart failure
por: Ji, Peng‐juan, et al.
Publicado: (2023)

Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria
por: Poulsen, Christina Gjerlev, et al.
Publicado: (2023)

Biopsy-Controlled Non-Invasive Quantification of Collagen Type VI in Kidney Transplant Recipients: A Post-Hoc Analysis of the MECANO Trial
por: Yepes-Calderón, Manuela, et al.
Publicado: (2020)

Tubuloglomerular Feedback in Renal Glucosuria: Mimicking Long-term SGLT-2 Inhibitor Therapy
por: Neuwirt, Hannes, et al.
Publicado: (2019)

Commentary: SGLT2is vs. GLP1RAs reduce cardiovascular and all-cause mortality
por: Du, Lixin, et al.
Publicado: (2022)

Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours
por: Park, Jiyoung, et al.
Publicado: (2013)

International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe
por: Thöni, Stefanie, et al.
Publicado: (2023)

In Reply to ‘Do SGLT-2 Inhibitors Act Only Through a Functional Tubuloglomerular Feedback Induced by the Increased Outflow of Sodium?’
por: Neuwirt, Hannes, et al.
Publicado: (2020)

Substantially different findings concerning the cardiovascular and cerebrovascular effectiveness of GLP1RAs vs. SGLT2is
por: Du, Lixin, et al.
Publicado: (2022)

Unique Biomarkers of Collagen Type III Remodeling Reflect Different Information Regarding Pathological Kidney Tissue Alterations in Patients with IgA Nephropathy
por: Sparding, Nadja, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bqtml7fultuf88r7n1e4r7nvss