DPH1 Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2

In eukaryotes, the Dph1•Dph2 dimer is a non-canonical radical SAM enzyme. Using iron-sulfur (FeS) clusters, it cleaves the cosubstrate S-adenosyl-methionine (SAM) to form a 3-amino-3-carboxy-propyl (ACP) radical for the synthesis of diphthamide. The latter decorates a histidine residue on elongation...

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Detalles Bibliográficos
Autores principales: Ütkür, Koray, Schmidt, Sarina, Mayer, Klaus, Klassen, Roland, Brinkmann, Ulrich, Schaffrath, Raffael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669111/
https://www.ncbi.nlm.nih.gov/pubmed/38002337
http://dx.doi.org/10.3390/biom13111655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669111/
https://www.ncbi.nlm.nih.gov/pubmed/38002337
http://dx.doi.org/10.3390/biom13111655

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