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Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing

Heart failure with preserved ejection fraction (HFpEF) is emerging as a widespread disease with global socioeconomic impact. Patients with HFpEF show a dramatically increased morbidity and mortality, and, unfortunately, specific treatment options are limited. This is due to the various etiologies th...

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Autores principales: Wester, Michael, Arzt, Michael, Sinha, Frederick, Maier, Lars Siegfried, Lebek, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669157/
https://www.ncbi.nlm.nih.gov/pubmed/38002038
http://dx.doi.org/10.3390/biomedicines11113038
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author Wester, Michael
Arzt, Michael
Sinha, Frederick
Maier, Lars Siegfried
Lebek, Simon
author_facet Wester, Michael
Arzt, Michael
Sinha, Frederick
Maier, Lars Siegfried
Lebek, Simon
author_sort Wester, Michael
collection PubMed
description Heart failure with preserved ejection fraction (HFpEF) is emerging as a widespread disease with global socioeconomic impact. Patients with HFpEF show a dramatically increased morbidity and mortality, and, unfortunately, specific treatment options are limited. This is due to the various etiologies that promote HFpEF development. Indeed, cluster analyses with common HFpEF comorbidities revealed the existence of several HFpEF phenotypes. One especially frequent, yet underappreciated, comorbidity is sleep-disordered breathing (SDB), which is closely intertwined with the development and progression of the “obese HFpEF phenotype”. The following review article aims to provide an overview of the common HFpEF etiologies and phenotypes, especially in the context of SDB. As general HFpEF therapies are often not successful, patient- and phenotype-individualized therapeutic strategies are warranted. Therefore, for the “obese HFpEF phenotype”, a better understanding of the mechanistic parallels between both HFpEF and SDB is required, which may help to identify potential phenotype-individualized therapeutic strategies. Novel technologies like single-cell transcriptomics or CRISPR-Cas9 gene editing further broaden the groundwork for deeper insights into pathomechanisms and precision medicine.
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spelling pubmed-106691572023-11-13 Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing Wester, Michael Arzt, Michael Sinha, Frederick Maier, Lars Siegfried Lebek, Simon Biomedicines Review Heart failure with preserved ejection fraction (HFpEF) is emerging as a widespread disease with global socioeconomic impact. Patients with HFpEF show a dramatically increased morbidity and mortality, and, unfortunately, specific treatment options are limited. This is due to the various etiologies that promote HFpEF development. Indeed, cluster analyses with common HFpEF comorbidities revealed the existence of several HFpEF phenotypes. One especially frequent, yet underappreciated, comorbidity is sleep-disordered breathing (SDB), which is closely intertwined with the development and progression of the “obese HFpEF phenotype”. The following review article aims to provide an overview of the common HFpEF etiologies and phenotypes, especially in the context of SDB. As general HFpEF therapies are often not successful, patient- and phenotype-individualized therapeutic strategies are warranted. Therefore, for the “obese HFpEF phenotype”, a better understanding of the mechanistic parallels between both HFpEF and SDB is required, which may help to identify potential phenotype-individualized therapeutic strategies. Novel technologies like single-cell transcriptomics or CRISPR-Cas9 gene editing further broaden the groundwork for deeper insights into pathomechanisms and precision medicine. MDPI 2023-11-13 /pmc/articles/PMC10669157/ /pubmed/38002038 http://dx.doi.org/10.3390/biomedicines11113038 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wester, Michael
Arzt, Michael
Sinha, Frederick
Maier, Lars Siegfried
Lebek, Simon
Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing
title Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing
title_full Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing
title_fullStr Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing
title_full_unstemmed Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing
title_short Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing
title_sort insights into the interaction of heart failure with preserved ejection fraction and sleep-disordered breathing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669157/
https://www.ncbi.nlm.nih.gov/pubmed/38002038
http://dx.doi.org/10.3390/biomedicines11113038
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