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Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate

Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep-related disorder. It is characterized by recurrent partial or total collapse of pharyngeal upper airway accompanied by induced vibrations of the soft tissues (e.g., soft palate). The knowledge of the tissue behavior subject to a particular ai...

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Detalles Bibliográficos
Autores principales: Li, Peng, Laudato, Marco, Mihaescu, Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669192/
https://www.ncbi.nlm.nih.gov/pubmed/38002437
http://dx.doi.org/10.3390/bioengineering10111313
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author Li, Peng
Laudato, Marco
Mihaescu, Mihai
author_facet Li, Peng
Laudato, Marco
Mihaescu, Mihai
author_sort Li, Peng
collection PubMed
description Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep-related disorder. It is characterized by recurrent partial or total collapse of pharyngeal upper airway accompanied by induced vibrations of the soft tissues (e.g., soft palate). The knowledge of the tissue behavior subject to a particular airflow is relevant for realistic clinic applications. However, in-vivo measurements are usually impractical. The goal of the present study is to develop a 3D fluid-structure interaction model for the human uvulopalatal system relevant to OSA based on simplified geometries under physiological conditions. Numerical simulations are performed to assess the influence of the different breathing conditions on the vibrational dynamics of the flexible structure. Meanwhile, the fluid patterns are investigated for the coupled fluid-structure system as well. Increasing the respiratory flow rate is shown to induce larger structural deformation. Vortex shedding induced resonance is not observed due to the large discrepancy between the flow oscillatory frequency and the natural frequency of the structure. The large deformation for symmetric breathing case under intensive respiration is mainly because of the positive feedback from the pressure differences on the top and the bottom surfaces of the structure.
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spelling pubmed-106691922023-11-14 Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate Li, Peng Laudato, Marco Mihaescu, Mihai Bioengineering (Basel) Article Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep-related disorder. It is characterized by recurrent partial or total collapse of pharyngeal upper airway accompanied by induced vibrations of the soft tissues (e.g., soft palate). The knowledge of the tissue behavior subject to a particular airflow is relevant for realistic clinic applications. However, in-vivo measurements are usually impractical. The goal of the present study is to develop a 3D fluid-structure interaction model for the human uvulopalatal system relevant to OSA based on simplified geometries under physiological conditions. Numerical simulations are performed to assess the influence of the different breathing conditions on the vibrational dynamics of the flexible structure. Meanwhile, the fluid patterns are investigated for the coupled fluid-structure system as well. Increasing the respiratory flow rate is shown to induce larger structural deformation. Vortex shedding induced resonance is not observed due to the large discrepancy between the flow oscillatory frequency and the natural frequency of the structure. The large deformation for symmetric breathing case under intensive respiration is mainly because of the positive feedback from the pressure differences on the top and the bottom surfaces of the structure. MDPI 2023-11-14 /pmc/articles/PMC10669192/ /pubmed/38002437 http://dx.doi.org/10.3390/bioengineering10111313 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Peng
Laudato, Marco
Mihaescu, Mihai
Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate
title Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate
title_full Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate
title_fullStr Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate
title_full_unstemmed Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate
title_short Time-Dependent Fluid-Structure Interaction Simulations of a Simplified Human Soft Palate
title_sort time-dependent fluid-structure interaction simulations of a simplified human soft palate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669192/
https://www.ncbi.nlm.nih.gov/pubmed/38002437
http://dx.doi.org/10.3390/bioengineering10111313
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