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Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells

Several plants of the genus Tragia L. have shown antibacterial, fungicidal, and antiproliferative activity, among other types of activities; however, most species of the genus have not been investigated. Tragia volubilis L. is native to tropical America and Africa, and although it has been reported...

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Autores principales: Bailon-Moscoso, Natalia, Coronel-Hidalgo, José, Duarte-Casar, Rodrigo, Guamán-Ortiz, Luis Miguel, Figueroa, Jorge G., Romero-Benavides, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669231/
https://www.ncbi.nlm.nih.gov/pubmed/38001856
http://dx.doi.org/10.3390/antiox12112003
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author Bailon-Moscoso, Natalia
Coronel-Hidalgo, José
Duarte-Casar, Rodrigo
Guamán-Ortiz, Luis Miguel
Figueroa, Jorge G.
Romero-Benavides, Juan Carlos
author_facet Bailon-Moscoso, Natalia
Coronel-Hidalgo, José
Duarte-Casar, Rodrigo
Guamán-Ortiz, Luis Miguel
Figueroa, Jorge G.
Romero-Benavides, Juan Carlos
author_sort Bailon-Moscoso, Natalia
collection PubMed
description Several plants of the genus Tragia L. have shown antibacterial, fungicidal, and antiproliferative activity, among other types of activities; however, most species of the genus have not been investigated. Tragia volubilis L. is native to tropical America and Africa, and although it has been reported as medicinal in the literature, it has not been thoroughly investigated. In this study, the phytochemical screening, isolation, and identification of compounds and the determination of the antioxidant activity of the aqueous extract of Tragia volubilis L. and its partitions were carried out. Ethyl acetate and n-butanol partitions of the extract present high antioxidant activity according to the Antioxidant Activity Index. Due to their activity, these partitions were tested on RKO cells as a representative model, both individually and in combination with Doxorubicin. It was found that the partitions significantly reduced the effect of Doxorubicin, as well as the expression of proteins involved in DNA damage and cell death. While the reduction of the chemotherapeutic effect of Doxorubicin on tumor cells may not be a desired outcome in therapeutic settings, the findings of the study are valuable in revealing the antioxidant potential of Tragia volubilis L. and its partitions. This highlights the importance of carefully regulating the application of antioxidants, especially in the context of cancer chemotherapy.
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spelling pubmed-106692312023-11-14 Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells Bailon-Moscoso, Natalia Coronel-Hidalgo, José Duarte-Casar, Rodrigo Guamán-Ortiz, Luis Miguel Figueroa, Jorge G. Romero-Benavides, Juan Carlos Antioxidants (Basel) Article Several plants of the genus Tragia L. have shown antibacterial, fungicidal, and antiproliferative activity, among other types of activities; however, most species of the genus have not been investigated. Tragia volubilis L. is native to tropical America and Africa, and although it has been reported as medicinal in the literature, it has not been thoroughly investigated. In this study, the phytochemical screening, isolation, and identification of compounds and the determination of the antioxidant activity of the aqueous extract of Tragia volubilis L. and its partitions were carried out. Ethyl acetate and n-butanol partitions of the extract present high antioxidant activity according to the Antioxidant Activity Index. Due to their activity, these partitions were tested on RKO cells as a representative model, both individually and in combination with Doxorubicin. It was found that the partitions significantly reduced the effect of Doxorubicin, as well as the expression of proteins involved in DNA damage and cell death. While the reduction of the chemotherapeutic effect of Doxorubicin on tumor cells may not be a desired outcome in therapeutic settings, the findings of the study are valuable in revealing the antioxidant potential of Tragia volubilis L. and its partitions. This highlights the importance of carefully regulating the application of antioxidants, especially in the context of cancer chemotherapy. MDPI 2023-11-14 /pmc/articles/PMC10669231/ /pubmed/38001856 http://dx.doi.org/10.3390/antiox12112003 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bailon-Moscoso, Natalia
Coronel-Hidalgo, José
Duarte-Casar, Rodrigo
Guamán-Ortiz, Luis Miguel
Figueroa, Jorge G.
Romero-Benavides, Juan Carlos
Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells
title Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells
title_full Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells
title_fullStr Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells
title_full_unstemmed Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells
title_short Exploring the Antioxidant Potential of Tragia volubilis L.: Mitigating Chemotherapeutic Effects of Doxorubicin on Tumor Cells
title_sort exploring the antioxidant potential of tragia volubilis l.: mitigating chemotherapeutic effects of doxorubicin on tumor cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669231/
https://www.ncbi.nlm.nih.gov/pubmed/38001856
http://dx.doi.org/10.3390/antiox12112003
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