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Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region

Failure in antibiotic therapies due to the increase in antimicrobial-resistant (AMR) bacteria is one of the main threats to public and animal health. In recent decades, the perception of companion animals has changed, from being considered as a work tool to a household member, creating a family bond...

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Autores principales: Marco-Fuertes, Ana, Jordá, Jaume, Marin, Clara, Lorenzo-Rebenaque, Laura, Montoro-Dasi, Laura, Vega, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669260/
https://www.ncbi.nlm.nih.gov/pubmed/37998840
http://dx.doi.org/10.3390/antibiotics12111638
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author Marco-Fuertes, Ana
Jordá, Jaume
Marin, Clara
Lorenzo-Rebenaque, Laura
Montoro-Dasi, Laura
Vega, Santiago
author_facet Marco-Fuertes, Ana
Jordá, Jaume
Marin, Clara
Lorenzo-Rebenaque, Laura
Montoro-Dasi, Laura
Vega, Santiago
author_sort Marco-Fuertes, Ana
collection PubMed
description Failure in antibiotic therapies due to the increase in antimicrobial-resistant (AMR) bacteria is one of the main threats to public and animal health. In recent decades, the perception of companion animals has changed, from being considered as a work tool to a household member, creating a family bond and sharing spaces in their daily routine. Hence, the aim of this study is to assess the current epidemiological situation regarding the presence of AMR and multidrug resistance (MDR) in companion animals in the Valencia Region, using the indicator bacteria Escherichia coli as a sentinel. For this purpose, 244 samples of dogs and cats were collected from veterinary centres to assess antimicrobial susceptibility against a panel of 22 antibiotics with public health relevance. A total of 197 E. coli strains were isolated from asymptomatic dogs and cats. The results showed AMR against all the 22 antibiotics studied, including those critically important to human medicine. Moreover, almost 50% of the strains presented MDR. The present study revealed the importance of monitoring AMR and MDR trends in companion animals, as they could pose a risk due to the spread of AMR and its resistance genes to humans, other animals and the environment they cohabit.
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spelling pubmed-106692602023-11-19 Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region Marco-Fuertes, Ana Jordá, Jaume Marin, Clara Lorenzo-Rebenaque, Laura Montoro-Dasi, Laura Vega, Santiago Antibiotics (Basel) Article Failure in antibiotic therapies due to the increase in antimicrobial-resistant (AMR) bacteria is one of the main threats to public and animal health. In recent decades, the perception of companion animals has changed, from being considered as a work tool to a household member, creating a family bond and sharing spaces in their daily routine. Hence, the aim of this study is to assess the current epidemiological situation regarding the presence of AMR and multidrug resistance (MDR) in companion animals in the Valencia Region, using the indicator bacteria Escherichia coli as a sentinel. For this purpose, 244 samples of dogs and cats were collected from veterinary centres to assess antimicrobial susceptibility against a panel of 22 antibiotics with public health relevance. A total of 197 E. coli strains were isolated from asymptomatic dogs and cats. The results showed AMR against all the 22 antibiotics studied, including those critically important to human medicine. Moreover, almost 50% of the strains presented MDR. The present study revealed the importance of monitoring AMR and MDR trends in companion animals, as they could pose a risk due to the spread of AMR and its resistance genes to humans, other animals and the environment they cohabit. MDPI 2023-11-19 /pmc/articles/PMC10669260/ /pubmed/37998840 http://dx.doi.org/10.3390/antibiotics12111638 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marco-Fuertes, Ana
Jordá, Jaume
Marin, Clara
Lorenzo-Rebenaque, Laura
Montoro-Dasi, Laura
Vega, Santiago
Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region
title Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region
title_full Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region
title_fullStr Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region
title_full_unstemmed Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region
title_short Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region
title_sort multidrug-resistant escherichia coli strains to last resort human antibiotics isolated from healthy companion animals in valencia region
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669260/
https://www.ncbi.nlm.nih.gov/pubmed/37998840
http://dx.doi.org/10.3390/antibiotics12111638
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