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Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study

This study harnessed machine learning to forecast postoperative mortality (POM) and postoperative pneumonia (PPN) among surgical traumatic brain injury (TBI) patients. Our analysis centered on the following key variables: Glasgow Coma Scale (GCS), midline brain shift (MSB), and time from injury to e...

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Autores principales: Kim, Jong-Ho, Chung, Kyung-Min, Lee, Jae-Jun, Choi, Hyuk-Jai, Kwon, Young-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669264/
https://www.ncbi.nlm.nih.gov/pubmed/38001880
http://dx.doi.org/10.3390/biomedicines11112880
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author Kim, Jong-Ho
Chung, Kyung-Min
Lee, Jae-Jun
Choi, Hyuk-Jai
Kwon, Young-Suk
author_facet Kim, Jong-Ho
Chung, Kyung-Min
Lee, Jae-Jun
Choi, Hyuk-Jai
Kwon, Young-Suk
author_sort Kim, Jong-Ho
collection PubMed
description This study harnessed machine learning to forecast postoperative mortality (POM) and postoperative pneumonia (PPN) among surgical traumatic brain injury (TBI) patients. Our analysis centered on the following key variables: Glasgow Coma Scale (GCS), midline brain shift (MSB), and time from injury to emergency room arrival (TIE). Additionally, we introduced innovative clustered variables to enhance predictive accuracy and risk assessment. Exploring data from 617 patients spanning 2012 to 2022, we observed that 22.9% encountered postoperative mortality, while 30.0% faced postoperative pneumonia (PPN). Sensitivity for POM and PPN prediction, before incorporating clustering, was in the ranges of 0.43–0.82 (POM) and 0.54–0.76 (PPN). Following clustering, sensitivity values were 0.47–0.76 (POM) and 0.61–0.77 (PPN). Accuracy was in the ranges of 0.67–0.76 (POM) and 0.70–0.81 (PPN) prior to clustering and 0.42–0.73 (POM) and 0.55–0.73 (PPN) after clustering. Clusters characterized by low GCS, small MSB, and short TIE exhibited a 3.2-fold higher POM risk compared to clusters with high GCS, small MSB, and short TIE. In summary, leveraging clustered variables offers a novel avenue for predicting POM and PPN in TBI patients. Assessing the amalgamated impact of GCS, MSB, and TIE characteristics provides valuable insights for clinical decision making.
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spelling pubmed-106692642023-10-24 Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study Kim, Jong-Ho Chung, Kyung-Min Lee, Jae-Jun Choi, Hyuk-Jai Kwon, Young-Suk Biomedicines Article This study harnessed machine learning to forecast postoperative mortality (POM) and postoperative pneumonia (PPN) among surgical traumatic brain injury (TBI) patients. Our analysis centered on the following key variables: Glasgow Coma Scale (GCS), midline brain shift (MSB), and time from injury to emergency room arrival (TIE). Additionally, we introduced innovative clustered variables to enhance predictive accuracy and risk assessment. Exploring data from 617 patients spanning 2012 to 2022, we observed that 22.9% encountered postoperative mortality, while 30.0% faced postoperative pneumonia (PPN). Sensitivity for POM and PPN prediction, before incorporating clustering, was in the ranges of 0.43–0.82 (POM) and 0.54–0.76 (PPN). Following clustering, sensitivity values were 0.47–0.76 (POM) and 0.61–0.77 (PPN). Accuracy was in the ranges of 0.67–0.76 (POM) and 0.70–0.81 (PPN) prior to clustering and 0.42–0.73 (POM) and 0.55–0.73 (PPN) after clustering. Clusters characterized by low GCS, small MSB, and short TIE exhibited a 3.2-fold higher POM risk compared to clusters with high GCS, small MSB, and short TIE. In summary, leveraging clustered variables offers a novel avenue for predicting POM and PPN in TBI patients. Assessing the amalgamated impact of GCS, MSB, and TIE characteristics provides valuable insights for clinical decision making. MDPI 2023-10-24 /pmc/articles/PMC10669264/ /pubmed/38001880 http://dx.doi.org/10.3390/biomedicines11112880 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Jong-Ho
Chung, Kyung-Min
Lee, Jae-Jun
Choi, Hyuk-Jai
Kwon, Young-Suk
Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study
title Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study
title_full Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study
title_fullStr Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study
title_full_unstemmed Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study
title_short Predictive Modeling and Integrated Risk Assessment of Postoperative Mortality and Pneumonia in Traumatic Brain Injury Patients through Clustering and Machine Learning: Retrospective Study
title_sort predictive modeling and integrated risk assessment of postoperative mortality and pneumonia in traumatic brain injury patients through clustering and machine learning: retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669264/
https://www.ncbi.nlm.nih.gov/pubmed/38001880
http://dx.doi.org/10.3390/biomedicines11112880
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