Cargando…

Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules

Chemical transdifferentiation is a technique that utilizes small molecules to directly convert one cell type into another without passing through an intermediate stem cell state. This technique offers several advantages over other methods of cell reprogramming, such as simplicity, standardization, v...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yu, Li, Xuefeng, Xing, Jianyu, Zhou, Jinsong, Li, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669320/
https://www.ncbi.nlm.nih.gov/pubmed/38001913
http://dx.doi.org/10.3390/biomedicines11112913
_version_ 1785139668633780224
author Zhang, Yu
Li, Xuefeng
Xing, Jianyu
Zhou, Jinsong
Li, Hai
author_facet Zhang, Yu
Li, Xuefeng
Xing, Jianyu
Zhou, Jinsong
Li, Hai
author_sort Zhang, Yu
collection PubMed
description Chemical transdifferentiation is a technique that utilizes small molecules to directly convert one cell type into another without passing through an intermediate stem cell state. This technique offers several advantages over other methods of cell reprogramming, such as simplicity, standardization, versatility, no ethical and safety concern and patient-specific therapies. Chemical transdifferentiation has been successfully applied to various cell types across different tissues and organs, and its potential applications are rapidly expanding as scientists continue to explore new combinations of small molecules and refine the mechanisms driving cell fate conversion. These applications have opened up new possibilities for regenerative medicine, disease modeling, drug discovery and tissue engineering. However, there are still challenges and limitations that need to be overcome before chemical transdifferentiation can be translated into clinical practice. These include low efficiency and reproducibility, incomplete understanding of the molecular mechanisms, long-term stability and functionality of the transdifferentiated cells, cell-type specificity and scalability. In this review, we compared the commonly used methods for cell transdifferentiation in recent years and discussed the current progress and future perspective of the chemical transdifferentiation of somatic cells and its potential impact on biomedicine. We believe that with ongoing research and technological advancements, the future holds tremendous promise for harnessing the power of small molecules to shape the cellular landscape and revolutionize the field of biomedicine.
format Online
Article
Text
id pubmed-10669320
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106693202023-10-27 Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules Zhang, Yu Li, Xuefeng Xing, Jianyu Zhou, Jinsong Li, Hai Biomedicines Review Chemical transdifferentiation is a technique that utilizes small molecules to directly convert one cell type into another without passing through an intermediate stem cell state. This technique offers several advantages over other methods of cell reprogramming, such as simplicity, standardization, versatility, no ethical and safety concern and patient-specific therapies. Chemical transdifferentiation has been successfully applied to various cell types across different tissues and organs, and its potential applications are rapidly expanding as scientists continue to explore new combinations of small molecules and refine the mechanisms driving cell fate conversion. These applications have opened up new possibilities for regenerative medicine, disease modeling, drug discovery and tissue engineering. However, there are still challenges and limitations that need to be overcome before chemical transdifferentiation can be translated into clinical practice. These include low efficiency and reproducibility, incomplete understanding of the molecular mechanisms, long-term stability and functionality of the transdifferentiated cells, cell-type specificity and scalability. In this review, we compared the commonly used methods for cell transdifferentiation in recent years and discussed the current progress and future perspective of the chemical transdifferentiation of somatic cells and its potential impact on biomedicine. We believe that with ongoing research and technological advancements, the future holds tremendous promise for harnessing the power of small molecules to shape the cellular landscape and revolutionize the field of biomedicine. MDPI 2023-10-27 /pmc/articles/PMC10669320/ /pubmed/38001913 http://dx.doi.org/10.3390/biomedicines11112913 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Yu
Li, Xuefeng
Xing, Jianyu
Zhou, Jinsong
Li, Hai
Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules
title Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules
title_full Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules
title_fullStr Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules
title_full_unstemmed Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules
title_short Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules
title_sort chemical transdifferentiation of somatic cells: unleashing the power of small molecules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669320/
https://www.ncbi.nlm.nih.gov/pubmed/38001913
http://dx.doi.org/10.3390/biomedicines11112913
work_keys_str_mv AT zhangyu chemicaltransdifferentiationofsomaticcellsunleashingthepowerofsmallmolecules
AT lixuefeng chemicaltransdifferentiationofsomaticcellsunleashingthepowerofsmallmolecules
AT xingjianyu chemicaltransdifferentiationofsomaticcellsunleashingthepowerofsmallmolecules
AT zhoujinsong chemicaltransdifferentiationofsomaticcellsunleashingthepowerofsmallmolecules
AT lihai chemicaltransdifferentiationofsomaticcellsunleashingthepowerofsmallmolecules