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Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

Particulate matter 2.5 (PM(2.5)) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM(2.5) affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dus...

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Autores principales: Park, Sunwha, Kwon, Eunjin, Lee, Gain, You, Young-Ah, Kim, Soo Min, Hur, Young Min, Jung, Sooyoung, Jee, Yongho, Park, Mi Hye, Na, Sung Hun, Kim, Young-Han, Cho, Geum Joon, Bae, Jin-Gon, Lee, Soo-Jeong, Lee, Sun Hwa, Kim, Young Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669397/
https://www.ncbi.nlm.nih.gov/pubmed/38001768
http://dx.doi.org/10.3390/antiox12111916
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author Park, Sunwha
Kwon, Eunjin
Lee, Gain
You, Young-Ah
Kim, Soo Min
Hur, Young Min
Jung, Sooyoung
Jee, Yongho
Park, Mi Hye
Na, Sung Hun
Kim, Young-Han
Cho, Geum Joon
Bae, Jin-Gon
Lee, Soo-Jeong
Lee, Sun Hwa
Kim, Young Ju
author_facet Park, Sunwha
Kwon, Eunjin
Lee, Gain
You, Young-Ah
Kim, Soo Min
Hur, Young Min
Jung, Sooyoung
Jee, Yongho
Park, Mi Hye
Na, Sung Hun
Kim, Young-Han
Cho, Geum Joon
Bae, Jin-Gon
Lee, Soo-Jeong
Lee, Sun Hwa
Kim, Young Ju
author_sort Park, Sunwha
collection PubMed
description Particulate matter 2.5 (PM(2.5)) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM(2.5) affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM(2.5) exposure levels. As a multicenter prospective cohort study, we measured the indoor PM(2.5) concentration and inflammatory and oxidative stress markers. The PM(2.5) concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m(3), which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m(3)) (p = 0.02). When the newborns were divided by sex, the PM(2.5) concentration of the LBW group was 27.89 μg/m(3) in male infants, which was significantly higher than that of the NBW group (26.26 μg/m(3)) (p = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (p < 0.01, p = 0.01). This study showed an association between PM(2.5), oxidative stress, and fetal growth, with the PTB group being more vulnerable.
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spelling pubmed-106693972023-10-26 Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress Park, Sunwha Kwon, Eunjin Lee, Gain You, Young-Ah Kim, Soo Min Hur, Young Min Jung, Sooyoung Jee, Yongho Park, Mi Hye Na, Sung Hun Kim, Young-Han Cho, Geum Joon Bae, Jin-Gon Lee, Soo-Jeong Lee, Sun Hwa Kim, Young Ju Antioxidants (Basel) Article Particulate matter 2.5 (PM(2.5)) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM(2.5) affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM(2.5) exposure levels. As a multicenter prospective cohort study, we measured the indoor PM(2.5) concentration and inflammatory and oxidative stress markers. The PM(2.5) concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m(3), which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m(3)) (p = 0.02). When the newborns were divided by sex, the PM(2.5) concentration of the LBW group was 27.89 μg/m(3) in male infants, which was significantly higher than that of the NBW group (26.26 μg/m(3)) (p = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (p < 0.01, p = 0.01). This study showed an association between PM(2.5), oxidative stress, and fetal growth, with the PTB group being more vulnerable. MDPI 2023-10-26 /pmc/articles/PMC10669397/ /pubmed/38001768 http://dx.doi.org/10.3390/antiox12111916 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Sunwha
Kwon, Eunjin
Lee, Gain
You, Young-Ah
Kim, Soo Min
Hur, Young Min
Jung, Sooyoung
Jee, Yongho
Park, Mi Hye
Na, Sung Hun
Kim, Young-Han
Cho, Geum Joon
Bae, Jin-Gon
Lee, Soo-Jeong
Lee, Sun Hwa
Kim, Young Ju
Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_full Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_fullStr Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_full_unstemmed Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_short Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
title_sort effect of particulate matter 2.5 on fetal growth in male and preterm infants through oxidative stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669397/
https://www.ncbi.nlm.nih.gov/pubmed/38001768
http://dx.doi.org/10.3390/antiox12111916
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