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Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets

Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are involved in the pathogenesis of this disorder. Trace...

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Autores principales: Vaganova, Anastasia N., Shemyakova, Taisiia S., Lenskaia, Karina V., Rodionov, Roman N., Steenblock, Charlotte, Gainetdinov, Raul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669413/
https://www.ncbi.nlm.nih.gov/pubmed/38002300
http://dx.doi.org/10.3390/biom13111618
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author Vaganova, Anastasia N.
Shemyakova, Taisiia S.
Lenskaia, Karina V.
Rodionov, Roman N.
Steenblock, Charlotte
Gainetdinov, Raul R.
author_facet Vaganova, Anastasia N.
Shemyakova, Taisiia S.
Lenskaia, Karina V.
Rodionov, Roman N.
Steenblock, Charlotte
Gainetdinov, Raul R.
author_sort Vaganova, Anastasia N.
collection PubMed
description Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are involved in the pathogenesis of this disorder. Trace amine-associated receptor 1 (TAAR1) is expressed in endocrine organs, and it was revealed that TAAR1 may regulate insulin secretion in pancreatic islet β-cells. For instance, accumulating data demonstrate the positive effect of TAAR1 agonists on the dynamics of metabolic syndrome progression and MetS-associated disease development. The role of other TAARs (TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) in the islet’s function is much less studied. In this review, we summarize the evidence of TAARs’ contribution to the metabolic syndrome pathogenesis and regulation of insulin secretion in pancreatic islets. Additionally, by the analysis of public transcriptomic data, we demonstrate that TAAR1 and other TAAR receptors are expressed in the pancreatic islets. We also explore associations between the expression of TAARs mRNA and other genes in studied samples and demonstrate the deregulation of TAARs’ functional associations in patients with metabolic diseases compared to healthy donors.
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spelling pubmed-106694132023-11-05 Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets Vaganova, Anastasia N. Shemyakova, Taisiia S. Lenskaia, Karina V. Rodionov, Roman N. Steenblock, Charlotte Gainetdinov, Raul R. Biomolecules Review Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are involved in the pathogenesis of this disorder. Trace amine-associated receptor 1 (TAAR1) is expressed in endocrine organs, and it was revealed that TAAR1 may regulate insulin secretion in pancreatic islet β-cells. For instance, accumulating data demonstrate the positive effect of TAAR1 agonists on the dynamics of metabolic syndrome progression and MetS-associated disease development. The role of other TAARs (TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) in the islet’s function is much less studied. In this review, we summarize the evidence of TAARs’ contribution to the metabolic syndrome pathogenesis and regulation of insulin secretion in pancreatic islets. Additionally, by the analysis of public transcriptomic data, we demonstrate that TAAR1 and other TAAR receptors are expressed in the pancreatic islets. We also explore associations between the expression of TAARs mRNA and other genes in studied samples and demonstrate the deregulation of TAARs’ functional associations in patients with metabolic diseases compared to healthy donors. MDPI 2023-11-05 /pmc/articles/PMC10669413/ /pubmed/38002300 http://dx.doi.org/10.3390/biom13111618 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vaganova, Anastasia N.
Shemyakova, Taisiia S.
Lenskaia, Karina V.
Rodionov, Roman N.
Steenblock, Charlotte
Gainetdinov, Raul R.
Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
title Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
title_full Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
title_fullStr Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
title_full_unstemmed Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
title_short Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
title_sort trace amine-associated receptors and monoamine-mediated regulation of insulin secretion in pancreatic islets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669413/
https://www.ncbi.nlm.nih.gov/pubmed/38002300
http://dx.doi.org/10.3390/biom13111618
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