Self-Cleavage of Human Chloride Channel Accessory 2 Causes a Conformational Shift That Depends on Membrane Anchorage and Is Required for Its Regulation of Store-Operated Calcium Entry

Human CLCA2 regulates store-operated calcium entry (SOCE) by interacting with Orai1 and STIM1. It is expressed as a 943aa type I transmembrane protein that is cleaved at amino acid 708 to produce a diffusible 100 kDa product. The N-terminal ectodomain contains a hydrolase-like subdomain with a conse...

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Detalles Bibliográficos
Autores principales: Ramena, Grace T., Sharma, Aarushi, Chang, Yan, Pan, Zui, Elble, Randolph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669480/
https://www.ncbi.nlm.nih.gov/pubmed/38001916
http://dx.doi.org/10.3390/biomedicines11112915

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