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Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress

Hemoglobin is one of the proteins that are more susceptible to S-glutathionylation and the levels of its modified form, glutathionyl hemoglobin (HbSSG), increase in several human pathological conditions. The scope of the present review is to provide knowledge about how hemoglobin is subjected to S-g...

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Autores principales: Scirè, Andrea, Casari, Giulia, Romaldi, Brenda, de Bari, Lidia, Antognelli, Cinzia, Armeni, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669486/
https://www.ncbi.nlm.nih.gov/pubmed/38001829
http://dx.doi.org/10.3390/antiox12111976
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author Scirè, Andrea
Casari, Giulia
Romaldi, Brenda
de Bari, Lidia
Antognelli, Cinzia
Armeni, Tatiana
author_facet Scirè, Andrea
Casari, Giulia
Romaldi, Brenda
de Bari, Lidia
Antognelli, Cinzia
Armeni, Tatiana
author_sort Scirè, Andrea
collection PubMed
description Hemoglobin is one of the proteins that are more susceptible to S-glutathionylation and the levels of its modified form, glutathionyl hemoglobin (HbSSG), increase in several human pathological conditions. The scope of the present review is to provide knowledge about how hemoglobin is subjected to S-glutathionylation and how this modification affects its functionality. The different diseases that showed increased levels of HbSSG and the methods used for its quantification in clinical investigations will be also outlined. Since there is a growing need for precise and reliable methods for markers of oxidative stress in human blood, this review highlights how HbSSG is emerging more and more as a good indicator of severe oxidative stress but also as a key pathogenic factor in several diseases.
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spelling pubmed-106694862023-11-07 Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress Scirè, Andrea Casari, Giulia Romaldi, Brenda de Bari, Lidia Antognelli, Cinzia Armeni, Tatiana Antioxidants (Basel) Review Hemoglobin is one of the proteins that are more susceptible to S-glutathionylation and the levels of its modified form, glutathionyl hemoglobin (HbSSG), increase in several human pathological conditions. The scope of the present review is to provide knowledge about how hemoglobin is subjected to S-glutathionylation and how this modification affects its functionality. The different diseases that showed increased levels of HbSSG and the methods used for its quantification in clinical investigations will be also outlined. Since there is a growing need for precise and reliable methods for markers of oxidative stress in human blood, this review highlights how HbSSG is emerging more and more as a good indicator of severe oxidative stress but also as a key pathogenic factor in several diseases. MDPI 2023-11-07 /pmc/articles/PMC10669486/ /pubmed/38001829 http://dx.doi.org/10.3390/antiox12111976 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scirè, Andrea
Casari, Giulia
Romaldi, Brenda
de Bari, Lidia
Antognelli, Cinzia
Armeni, Tatiana
Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress
title Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress
title_full Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress
title_fullStr Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress
title_full_unstemmed Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress
title_short Glutathionyl Hemoglobin and Its Emerging Role as a Clinical Biomarker of Chronic Oxidative Stress
title_sort glutathionyl hemoglobin and its emerging role as a clinical biomarker of chronic oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669486/
https://www.ncbi.nlm.nih.gov/pubmed/38001829
http://dx.doi.org/10.3390/antiox12111976
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