Cargando…

An Update on the Interplay between LRRK2, Rab GTPases and Parkinson’s Disease

Over the last decades, research on the pathobiology of neurodegenerative diseases has greatly evolved, revealing potential targets and mechanisms linked to their pathogenesis. Parkinson’s disease (PD) is no exception, and recent studies point to the involvement of endolysosomal defects in PD. The en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Komori, Tadayuki, Kuwahara, Tomoki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669493/ https://www.ncbi.nlm.nih.gov/pubmed/38002327 http://dx.doi.org/10.3390/biom13111645

Ejemplares similares

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System
por: Kuwahara, Tomoki, et al.
Publicado: (2020)

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
por: Eguchi, Tomoya, et al.
Publicado: (2018)

Rab GTPases as Physiological Substrates of LRRK2 Kinase
por: Seol, Wongi, et al.
Publicado: (2019)

Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2
por: Komori, Tadayuki, et al.
Publicado: (2023)

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
por: Steger, Martin, et al.
Publicado: (2016)

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
por: Jeong, Ga Ram, et al.
Publicado: (2018)

Dual arginine recognition of LRRK2 phosphorylated Rab GTPases
por: Waschbüsch, Dieter, et al.
Publicado: (2021)

Contribution of GTPase activity to LRRK2-associated Parkinson disease
por: Tsika, Elpida, et al.
Publicado: (2013)

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases
por: Gomez, Rachel C., et al.
Publicado: (2019)

Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis
por: Yeshaw, Wondwossen M., et al.
Publicado: (2023)

Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase
por: Purlyte, Elena, et al.
Publicado: (2017)

Rab GTPases in Parkinson's disease: a primer
por: Lara Ordóñez, Antonio Jesús, et al.
Publicado: (2021)

The atypical Rab GTPase associated with Parkinson’s disease, Rab29, is localized to membranes
por: Nagai-Ito, Yuki, et al.
Publicado: (2022)

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
por: Steger, Martin, et al.
Publicado: (2017)

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
por: Stafa, Klodjan, et al.
Publicado: (2014)

Rab GTPases: Switching to Human Diseases
por: Guadagno, Noemi Antonella, et al.
Publicado: (2019)

Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts
por: Petropoulou-Vathi, Lilian, et al.
Publicado: (2022)

Rab GTPases: The Key Players in the Molecular Pathway of Parkinson’s Disease
por: Shi, Meng-meng, et al.
Publicado: (2017)

Rab family of small GTPases: an updated view on their regulation and functions
por: Homma, Yuta, et al.
Publicado: (2020)

The Rab GTPase family
por: Stenmark, Harald, et al.
Publicado: (2001)

Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers
por: Taymans, Jean-Marc, et al.
Publicado: (2023)

Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson’s Disease
por: Martínez-Menárguez, José Ángel, et al.
Publicado: (2021)

LRRK2 and Proteostasis in Parkinson’s Disease
por: Pérez-Carrión, María Dolores, et al.
Publicado: (2022)

The Regulation of Rab GTPases by Phosphorylation
por: Xu, Lejia, et al.
Publicado: (2021)

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
por: Kuwahara, Tomoki, et al.
Publicado: (2016)

GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1
por: Stafa, Klodjan, et al.
Publicado: (2012)

LRRK2 and the Endolysosomal System in Parkinson’s Disease
por: Erb, Madalynn L., et al.
Publicado: (2020)

LRRK2 at the Crossroad of Aging and Parkinson’s Disease
por: Hur, Eun-Mi, et al.
Publicado: (2021)

Pathological Functions of LRRK2 in Parkinson’s Disease
por: Jeong, Ga Ram, et al.
Publicado: (2020)

Rabs on the fly: Functions of Rab GTPases during development
por: Caviglia, Sara, et al.
Publicado: (2017)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

Rab GTPases in cilium formation and function
por: Blacque, Oliver E., et al.
Publicado: (2017)

Role of Rab GTPases in Hepatocellular Carcinoma
por: Yang, Chun-Cheng, et al.
Publicado: (2021)

Rab GTPases as Modulators of Vascular Function
por: Raghavan, Somasundaram, et al.
Publicado: (2022)

Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease
por: Jordan, Kate L., et al.
Publicado: (2022)

Are There Rab GTPases in Archaea?
por: Surkont, Jaroslaw, et al.
Publicado: (2016)

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation
por: Fasiczka, Rachel, et al.
Publicado: (2023)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
por: Lis, Pawel, et al.
Publicado: (2018)

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils
por: Fan, Ying, et al.
Publicado: (2018)

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
por: Madero-Pérez, Jesús, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nsfii41htn6c4en1ltfbfuspdg