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Brain Iron Homeostasis and Mental Disorders

Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders and iron homeostasis has no...

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Detalles Bibliográficos
Autores principales: Wu, Qiong, Ren, Qiuyang, Meng, Jingsi, Gao, Wei-Juan, Chang, Yan-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669508/
https://www.ncbi.nlm.nih.gov/pubmed/38001850
http://dx.doi.org/10.3390/antiox12111997
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author Wu, Qiong
Ren, Qiuyang
Meng, Jingsi
Gao, Wei-Juan
Chang, Yan-Zhong
author_facet Wu, Qiong
Ren, Qiuyang
Meng, Jingsi
Gao, Wei-Juan
Chang, Yan-Zhong
author_sort Wu, Qiong
collection PubMed
description Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders and iron homeostasis has not received significant attention. Therefore, our understanding of iron metabolism in the context of psychological diseases is incomplete. In this review, we aim to discuss the pathologies and potential mechanisms that relate to iron homeostasis in associated mental disorders. We propose the hypothesis that maintaining brain iron homeostasis can support neuronal physiological functions by impacting key enzymatic activities during neurotransmission, redox balance, and myelination. In conclusion, our review highlights the importance of investigating the relationship between trace element nutrition and the pathological process of mental disorders, focusing on iron. This nutritional perspective can offer valuable insights for the clinical treatment of mental disorders.
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spelling pubmed-106695082023-11-13 Brain Iron Homeostasis and Mental Disorders Wu, Qiong Ren, Qiuyang Meng, Jingsi Gao, Wei-Juan Chang, Yan-Zhong Antioxidants (Basel) Review Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders and iron homeostasis has not received significant attention. Therefore, our understanding of iron metabolism in the context of psychological diseases is incomplete. In this review, we aim to discuss the pathologies and potential mechanisms that relate to iron homeostasis in associated mental disorders. We propose the hypothesis that maintaining brain iron homeostasis can support neuronal physiological functions by impacting key enzymatic activities during neurotransmission, redox balance, and myelination. In conclusion, our review highlights the importance of investigating the relationship between trace element nutrition and the pathological process of mental disorders, focusing on iron. This nutritional perspective can offer valuable insights for the clinical treatment of mental disorders. MDPI 2023-11-13 /pmc/articles/PMC10669508/ /pubmed/38001850 http://dx.doi.org/10.3390/antiox12111997 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Qiong
Ren, Qiuyang
Meng, Jingsi
Gao, Wei-Juan
Chang, Yan-Zhong
Brain Iron Homeostasis and Mental Disorders
title Brain Iron Homeostasis and Mental Disorders
title_full Brain Iron Homeostasis and Mental Disorders
title_fullStr Brain Iron Homeostasis and Mental Disorders
title_full_unstemmed Brain Iron Homeostasis and Mental Disorders
title_short Brain Iron Homeostasis and Mental Disorders
title_sort brain iron homeostasis and mental disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669508/
https://www.ncbi.nlm.nih.gov/pubmed/38001850
http://dx.doi.org/10.3390/antiox12111997
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