PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic–Ischemic Encephalopathy via Inhibition of AKT/GSK3β Signaling

We recently identified protein kinase N1 (PKN1) as a negative gatekeeper of neuronal AKT protein kinase activity during postnatal cerebellar development. The developing cerebellum is specifically vulnerable to hypoxia-ischemia (HI), as it occurs during hypoxic-ischemic encephalopathy, a condition ty...

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Detalles Bibliográficos
Autores principales: zur Nedden, Stephanie, Safari, Motahareh Solina, Fresser, Friedrich, Faserl, Klaus, Lindner, Herbert, Sarg, Bettina, Baier, Gottfried, Baier-Bitterlich, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669522/
https://www.ncbi.nlm.nih.gov/pubmed/38002281
http://dx.doi.org/10.3390/biom13111599

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