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Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or...

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Autores principales: Čižmáriková, Martina, Michalková, Radka, Mirossay, Ladislav, Mojžišová, Gabriela, Zigová, Martina, Bardelčíková, Annamária, Mojžiš, Ján
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669545/
https://www.ncbi.nlm.nih.gov/pubmed/38002335
http://dx.doi.org/10.3390/biom13111653
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author Čižmáriková, Martina
Michalková, Radka
Mirossay, Ladislav
Mojžišová, Gabriela
Zigová, Martina
Bardelčíková, Annamária
Mojžiš, Ján
author_facet Čižmáriková, Martina
Michalková, Radka
Mirossay, Ladislav
Mojžišová, Gabriela
Zigová, Martina
Bardelčíková, Annamária
Mojžiš, Ján
author_sort Čižmáriková, Martina
collection PubMed
description Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease.
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spelling pubmed-106695452023-11-15 Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence Čižmáriková, Martina Michalková, Radka Mirossay, Ladislav Mojžišová, Gabriela Zigová, Martina Bardelčíková, Annamária Mojžiš, Ján Biomolecules Review Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease. MDPI 2023-11-15 /pmc/articles/PMC10669545/ /pubmed/38002335 http://dx.doi.org/10.3390/biom13111653 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Čižmáriková, Martina
Michalková, Radka
Mirossay, Ladislav
Mojžišová, Gabriela
Zigová, Martina
Bardelčíková, Annamária
Mojžiš, Ján
Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
title Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
title_full Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
title_fullStr Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
title_full_unstemmed Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
title_short Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
title_sort ellagic acid and cancer hallmarks: insights from experimental evidence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669545/
https://www.ncbi.nlm.nih.gov/pubmed/38002335
http://dx.doi.org/10.3390/biom13111653
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