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Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669545/ https://www.ncbi.nlm.nih.gov/pubmed/38002335 http://dx.doi.org/10.3390/biom13111653 |
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author | Čižmáriková, Martina Michalková, Radka Mirossay, Ladislav Mojžišová, Gabriela Zigová, Martina Bardelčíková, Annamária Mojžiš, Ján |
author_facet | Čižmáriková, Martina Michalková, Radka Mirossay, Ladislav Mojžišová, Gabriela Zigová, Martina Bardelčíková, Annamária Mojžiš, Ján |
author_sort | Čižmáriková, Martina |
collection | PubMed |
description | Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease. |
format | Online Article Text |
id | pubmed-10669545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106695452023-11-15 Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence Čižmáriková, Martina Michalková, Radka Mirossay, Ladislav Mojžišová, Gabriela Zigová, Martina Bardelčíková, Annamária Mojžiš, Ján Biomolecules Review Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease. MDPI 2023-11-15 /pmc/articles/PMC10669545/ /pubmed/38002335 http://dx.doi.org/10.3390/biom13111653 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Čižmáriková, Martina Michalková, Radka Mirossay, Ladislav Mojžišová, Gabriela Zigová, Martina Bardelčíková, Annamária Mojžiš, Ján Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence |
title | Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence |
title_full | Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence |
title_fullStr | Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence |
title_full_unstemmed | Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence |
title_short | Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence |
title_sort | ellagic acid and cancer hallmarks: insights from experimental evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669545/ https://www.ncbi.nlm.nih.gov/pubmed/38002335 http://dx.doi.org/10.3390/biom13111653 |
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