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Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review

Parkinson’s Disease (PD) has historically been considered a disorder of motor dysfunction. However, a growing number of studies have demonstrated sensory abnormalities in PD across the modalities of proprioceptive, tactile, visual, auditory and temporal perception. A better understanding of these ma...

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Detalles Bibliográficos
Autores principales: Permezel, Fiona, Alty, Jane, Harding, Ian H., Thyagarajan, Dominic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669548/
https://www.ncbi.nlm.nih.gov/pubmed/38002513
http://dx.doi.org/10.3390/brainsci13111552
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author Permezel, Fiona
Alty, Jane
Harding, Ian H.
Thyagarajan, Dominic
author_facet Permezel, Fiona
Alty, Jane
Harding, Ian H.
Thyagarajan, Dominic
author_sort Permezel, Fiona
collection PubMed
description Parkinson’s Disease (PD) has historically been considered a disorder of motor dysfunction. However, a growing number of studies have demonstrated sensory abnormalities in PD across the modalities of proprioceptive, tactile, visual, auditory and temporal perception. A better understanding of these may inform future drug and neuromodulation therapy. We analysed these studies using a scoping review. In total, 101 studies comprising 2853 human participants (88 studies) and 125 animals (13 studies), published between 1982 and 2022, were included. These highlighted the importance of the basal ganglia in sensory perception across all modalities, with an additional role for the integration of multiple simultaneous sensation types. Numerous studies concluded that sensory abnormalities in PD result from increased noise in the basal ganglia and increased neuronal receptive field size. There is evidence that sensory changes in PD and impaired sensorimotor integration may contribute to motor abnormalities.
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spelling pubmed-106695482023-11-06 Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review Permezel, Fiona Alty, Jane Harding, Ian H. Thyagarajan, Dominic Brain Sci Review Parkinson’s Disease (PD) has historically been considered a disorder of motor dysfunction. However, a growing number of studies have demonstrated sensory abnormalities in PD across the modalities of proprioceptive, tactile, visual, auditory and temporal perception. A better understanding of these may inform future drug and neuromodulation therapy. We analysed these studies using a scoping review. In total, 101 studies comprising 2853 human participants (88 studies) and 125 animals (13 studies), published between 1982 and 2022, were included. These highlighted the importance of the basal ganglia in sensory perception across all modalities, with an additional role for the integration of multiple simultaneous sensation types. Numerous studies concluded that sensory abnormalities in PD result from increased noise in the basal ganglia and increased neuronal receptive field size. There is evidence that sensory changes in PD and impaired sensorimotor integration may contribute to motor abnormalities. MDPI 2023-11-06 /pmc/articles/PMC10669548/ /pubmed/38002513 http://dx.doi.org/10.3390/brainsci13111552 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Permezel, Fiona
Alty, Jane
Harding, Ian H.
Thyagarajan, Dominic
Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review
title Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review
title_full Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review
title_fullStr Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review
title_full_unstemmed Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review
title_short Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review
title_sort brain networks involved in sensory perception in parkinson’s disease: a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669548/
https://www.ncbi.nlm.nih.gov/pubmed/38002513
http://dx.doi.org/10.3390/brainsci13111552
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