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Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review
Parkinson’s Disease (PD) has historically been considered a disorder of motor dysfunction. However, a growing number of studies have demonstrated sensory abnormalities in PD across the modalities of proprioceptive, tactile, visual, auditory and temporal perception. A better understanding of these ma...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669548/ https://www.ncbi.nlm.nih.gov/pubmed/38002513 http://dx.doi.org/10.3390/brainsci13111552 |
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author | Permezel, Fiona Alty, Jane Harding, Ian H. Thyagarajan, Dominic |
author_facet | Permezel, Fiona Alty, Jane Harding, Ian H. Thyagarajan, Dominic |
author_sort | Permezel, Fiona |
collection | PubMed |
description | Parkinson’s Disease (PD) has historically been considered a disorder of motor dysfunction. However, a growing number of studies have demonstrated sensory abnormalities in PD across the modalities of proprioceptive, tactile, visual, auditory and temporal perception. A better understanding of these may inform future drug and neuromodulation therapy. We analysed these studies using a scoping review. In total, 101 studies comprising 2853 human participants (88 studies) and 125 animals (13 studies), published between 1982 and 2022, were included. These highlighted the importance of the basal ganglia in sensory perception across all modalities, with an additional role for the integration of multiple simultaneous sensation types. Numerous studies concluded that sensory abnormalities in PD result from increased noise in the basal ganglia and increased neuronal receptive field size. There is evidence that sensory changes in PD and impaired sensorimotor integration may contribute to motor abnormalities. |
format | Online Article Text |
id | pubmed-10669548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106695482023-11-06 Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review Permezel, Fiona Alty, Jane Harding, Ian H. Thyagarajan, Dominic Brain Sci Review Parkinson’s Disease (PD) has historically been considered a disorder of motor dysfunction. However, a growing number of studies have demonstrated sensory abnormalities in PD across the modalities of proprioceptive, tactile, visual, auditory and temporal perception. A better understanding of these may inform future drug and neuromodulation therapy. We analysed these studies using a scoping review. In total, 101 studies comprising 2853 human participants (88 studies) and 125 animals (13 studies), published between 1982 and 2022, were included. These highlighted the importance of the basal ganglia in sensory perception across all modalities, with an additional role for the integration of multiple simultaneous sensation types. Numerous studies concluded that sensory abnormalities in PD result from increased noise in the basal ganglia and increased neuronal receptive field size. There is evidence that sensory changes in PD and impaired sensorimotor integration may contribute to motor abnormalities. MDPI 2023-11-06 /pmc/articles/PMC10669548/ /pubmed/38002513 http://dx.doi.org/10.3390/brainsci13111552 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Permezel, Fiona Alty, Jane Harding, Ian H. Thyagarajan, Dominic Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review |
title | Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review |
title_full | Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review |
title_fullStr | Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review |
title_full_unstemmed | Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review |
title_short | Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review |
title_sort | brain networks involved in sensory perception in parkinson’s disease: a scoping review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669548/ https://www.ncbi.nlm.nih.gov/pubmed/38002513 http://dx.doi.org/10.3390/brainsci13111552 |
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