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Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis

Autologous micrografting technology (AMT(®)) involves the use of autologous micrografts to stimulate/enhance the repair of damaged tissue. This study assessed the efficacy and safety of the AMT(®) procedure in patients with early stages of knee osteoarthritis. Briefly, the AMT(®) procedure involved...

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Autores principales: Tsoukas, Dimitrios, Muntean, Ilie, Simos, Christos, Sabido-Vera, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669557/
https://www.ncbi.nlm.nih.gov/pubmed/38002418
http://dx.doi.org/10.3390/bioengineering10111294
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author Tsoukas, Dimitrios
Muntean, Ilie
Simos, Christos
Sabido-Vera, Ruben
author_facet Tsoukas, Dimitrios
Muntean, Ilie
Simos, Christos
Sabido-Vera, Ruben
author_sort Tsoukas, Dimitrios
collection PubMed
description Autologous micrografting technology (AMT(®)) involves the use of autologous micrografts to stimulate/enhance the repair of damaged tissue. This study assessed the efficacy and safety of the AMT(®) procedure in patients with early stages of knee osteoarthritis. Briefly, the AMT(®) procedure involved extraction of auricular cartilage, disaggregation using the Rigeneracons(®) SRT in 4.0 mL of saline solution, and injection of the disaggregated micrografts into the external femorotibial compartment area of the affected knee. Ten patients (4 men, 6 women; age range: 37–84 years) were included in the study. In all patients, there was a steady improvement in knee instability, pain, swelling, mechanical locking, stair climbing, and squatting at 1- and 6-months post-procedure. Improvement in mobility was observed as early as 3 weeks post-procedure in 2 patients. Significant improvements were seen in mean scores of all five subscales of Knee Injury and Osteoarthritis Outcome Score (KOOS [KOOS symptoms, KOOS pain, KOOS ADL, KOOS sport and recreation, and KOOS quality-of-life]) between pre-procedure and 1- and 6-months post-procedure (all p ≤ 0.05). Autologous auricular cartilage micrografts obtained by AMT(®) procedure (using Rigenera(®) technology) is an effective and safe protocol in the treatment of early stage knee osteoarthritis. These encouraging findings need to be validated in a larger patient population and in a randomized clinical trial (RCT).
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spelling pubmed-106695572023-11-08 Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis Tsoukas, Dimitrios Muntean, Ilie Simos, Christos Sabido-Vera, Ruben Bioengineering (Basel) Article Autologous micrografting technology (AMT(®)) involves the use of autologous micrografts to stimulate/enhance the repair of damaged tissue. This study assessed the efficacy and safety of the AMT(®) procedure in patients with early stages of knee osteoarthritis. Briefly, the AMT(®) procedure involved extraction of auricular cartilage, disaggregation using the Rigeneracons(®) SRT in 4.0 mL of saline solution, and injection of the disaggregated micrografts into the external femorotibial compartment area of the affected knee. Ten patients (4 men, 6 women; age range: 37–84 years) were included in the study. In all patients, there was a steady improvement in knee instability, pain, swelling, mechanical locking, stair climbing, and squatting at 1- and 6-months post-procedure. Improvement in mobility was observed as early as 3 weeks post-procedure in 2 patients. Significant improvements were seen in mean scores of all five subscales of Knee Injury and Osteoarthritis Outcome Score (KOOS [KOOS symptoms, KOOS pain, KOOS ADL, KOOS sport and recreation, and KOOS quality-of-life]) between pre-procedure and 1- and 6-months post-procedure (all p ≤ 0.05). Autologous auricular cartilage micrografts obtained by AMT(®) procedure (using Rigenera(®) technology) is an effective and safe protocol in the treatment of early stage knee osteoarthritis. These encouraging findings need to be validated in a larger patient population and in a randomized clinical trial (RCT). MDPI 2023-11-08 /pmc/articles/PMC10669557/ /pubmed/38002418 http://dx.doi.org/10.3390/bioengineering10111294 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsoukas, Dimitrios
Muntean, Ilie
Simos, Christos
Sabido-Vera, Ruben
Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis
title Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis
title_full Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis
title_fullStr Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis
title_full_unstemmed Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis
title_short Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis
title_sort prospective observational study of a non-arthroscopic autologous cartilage micrografting technology for knee osteoarthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669557/
https://www.ncbi.nlm.nih.gov/pubmed/38002418
http://dx.doi.org/10.3390/bioengineering10111294
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